8 result(s) for 'P63'
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Hintergrund des Antigens
p63 ist ein Mitglied der p53-Genfamilie und kodiert für mindestens sechs wichtige Immunglobulinisotypen mit transaktivierenden, todinduzierenden (TAp63) sowie dominant-negativen Aktivitäten (deltaNp63).
Das p63-Protein soll in einer Vielzahl gesunden Gewebes einschließlich proliferierender Zellen des Epithels, Gebärmutterhals, Urothel und Prostata exprimiert werden.
Das p63-Protein wird gleichfalls in den meisten schlecht...
Hintergründe des Antigensp40 (Delta Np63) ist ein gekürztes Produkt von p63. Es wird für gewöhnlich in der Basal- oder Vorläuferzellschicht von mehrschichtigen Epithelien, in den Basalzellen der Prostata sowie in den Myoepithelzellen der Brust und der Speicheldrüsen, und Zytotrophoblasten in der Plazenta exprimiert und zeigt mit IHC ein nukleares Färbemuster. Unter den zahlreichen Neoplasmen mit positiven p40-Markern können Plattenzellkarzinome m...
It’s Time for TIME Alexander “Sandy” Borowsky Professor of Pathology and Laboratory Medicine Center for Immunology and Infectious Diseases
Disclosures Bristol-Meyers Squibb/Celgene: Funded through Investigator Sponsored Research (ISR) program. Discovery proposal. Leica/Aperio: Funded to run the “Genesis” study for primary diagnosis from whole slide images. Honorarium for this presentation. Histolix: Slide-free histology (Levenson and Fereidouni). Pfizer: Pfizer Protocol A9001502, Treatment Resistance Following Therapies (TRANSLATE) site PI. Agenda: In contracting to join the “FLEX” registry. None of these has actually paid me, only funding for the research projects.
Objectives • Introduction into the complexity of the TIME and the development of new cancer treatments though di...
Biomarkers
AE1/AE3 (1)
AMACR (2)
BCL6 (1)
CD163 (2)
CD20 (2)
CD3 (9)
CD4 (5)
CD68 (5)
CD8 (10)
CDX2 (2)
CK20 (5)
Ck5 (4)
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In surgical pathology more than ever, the laboratories are expected to do more with less. Taking on more specimens with less technical staff, or getting more stains out of tiny biopsies or fine needle aspirations have become the norm. The College of American...
The content of this webinar will encompass detailed technical descriptions of novel and state of the art methods to decalcify tissue samples that will be embedded in paraffin or for frozen sectioning for molecular and nucleic acid analysis for basic research...
Slide 1
Hello, hello; thank you so much for that introduction. Let's get started. Oh, I'm sorry, I just need to hit this next button here. So my name is Mark Lawson.
Thank you for joining us in this webinar. I'm here to present BOND RX tips, tricks, and optimization. It's going to be a user guide from the BOND RX and chromogenic multiplexing in the research application.
Slide 2
So, my name is Mark Lawson. I'm an application specialist on the Life Sciences team at Leica Biosystems I provide technical support for the Life Sciences portfolio, including but not limited to the BOND RX, the BOND RXm, and a wide array of reagents. So I've worked in the histology field for about 15 years and in both clinical and research spaces. I started off as a histotechnologist and worked my way up...
Different types of cancers frequently metastase to bone tissue. Treatment planning decisions are often based upon histology and special staining of these distant sites of disease. These decisions may rely on the outcome of immunohistochemistry, in situ...