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Cytokeratin 7 Primary Antibodies

Cytokeratin 7

Infiltrating lobular carcinoma of breast: immunohistochemical staining for cytokeratin 7 antigen using NCL-L-CK7-560. Note intense membrane and cytoplasmic staining of malignant cells. Paraffin section.
Infiltrating lobular carcinoma of breast: immunohistochemical staining for cytokeratin 7 antigen using NCL-L-CK7-560. Note intense membrane and cytoplasmic staining of malignant cells. Paraffin section.

Antigen Background

Cytokeratins are intermediate filament proteins present in epithelial cells. They are expressed in a tissue-specific manner in normal organs and the tumors that arise from them. Cytokeratin 7 belongs to the neutral basic type B subfamily of cytokeratins. Its distribution is confined to glandular and transitional epithelia. Cytokeratin 7 is reported to be expressed in abundance in cultured bronchial and mesothelial cells but only at lower levels in cultured epidermal cells. The predicted amino acid sequence of this keratin has revealed a striking difference between this keratin and the type II keratins expressed in epidermal cells. Cytokeratin 7 has been reported in adenocarcinomas of the lung, breast, endometrium, ovary, thyroid as well as in carcinomas of the bladder and chromophobe renal cell carcinoma. Cytokeratin 7 and Cytokeratin 20 expression have been reported to show characteristic patterns on primary and metastatic lung and colorectal adenocarcinomas.

Product Specific Information

Where clone OV-TL 12/30 can produce unwanted staining of endothelial cells, clone RN7 does not stain these cell types. The choice of epitope retrieval, heat or enzyme, to provide the best result with clone OV-TL 12/30 should be determined by the user. Clones RN7 and OV-TL 12/30 react with the human cytokeratin intermediate filament protein (54 kD) identified as cytokeratin 7.


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CLONE: OV-TL12/30

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Code Name Configuration Use Datasheet MSDS Qty
CK7-OVTL-L 1ml NCL-L-CK7-OVTL Liquid Concentrated Monoclonal Antibody F, P(ENZYME/HIER), W Info MSDS
CK7-OVTL-L-CE 1ml NCL-L-CK7-OVTL Liquid Concentrated Monoclonal Antibody P(ENZYME/HIER) Info MSDS
CK7-OVTL-R-7-CE 7ml RTU-CK7-OVTL Ready to Use Monoclonal Antibody P(ENZYME/HIER) Info MSDS
CK7-OVTL-R-7 7ml RTU-CK7-OVTL Ready to Use Monoclonal Antibody F, P(ENZYME/HIER) Info MSDS

CLONE: RN7

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Code Name Configuration Use Datasheet MSDS Qty
PA0942 7ml Cytokeratin 7 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
PA0138 30ml Cytokeratin 7 Bond RTU Primary Bond ready to use reagent P(HIER) Info MSDS
CK7-560-L 1ml NCL-L-CK7-560 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
CK7-560-L-S 0.1ml NCL-L-CK7-560 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
CK7-560-L-CE 1ml NCL-L-CK7-560 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS
CK7-560-L-CE-S 0.1ml NCL-L-CK7-560 Liquid Concentrated Monoclonal Antibody P(HIER) Info MSDS