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HistoCore BIOCUT R - Mechanical Manual Rotary Microtome

149BIOR00C1, 14052158201

New Worlds Discovered - Research Reimagined

Faster Trimming and Consistent Cuts for all your Research Needs

HistoCore BIOCUT R facilitates faster trimming thanks to the new coarse feed wheel that lets you customize the direction of rotation. Built on 145+ years of market-leading microtomes, Leica Biosystems offers the next generation of microtomes with specially designed models for serial cutting with the actively cooled RM CoolClamp, which keeps the block cold longer for consistent slice thickness over multiple sections.

  • Advance or retract the specimen according to your preference by manually turning the Personalized Coarse Feed Wheel.
  • The new model allows you to switch between high and low-profile blades even faster without changing blade holders by using the 2-in-1 Blade Holder.
  • Silent retraction produces little to no noise, allowing the user to work in a quiet environment, creating a comfortable user experience.
Select a configuration


Product Specifications


Type: Mechanical
Nominal Supply Voltage: N/A
Nominal Frequency: N/A
Maximum Power Consumption: N/A
Protection Class: N/A
Power Fuses: N/A
Pollution Degree: N/A
Overvoltage Category: N/A
Maximum Heat Emission: N/A
Operating Temperature Range: +18°C to +30°C
Temperature Range During Storage: +5°C to +50°C
Relative Humidity During Operation: 20% to Max. 80% Non-Condensing
Relative Humidity During Storage: 10% to Max. 85% Non-Condensing

Dimensions & Weight

Width (including handwheel and coarse feed wheel): 477 mm
Depth (including waste tray): 620 mm
Height (without top tray): 295 mm
Weight (without accessories): Approx. 31 kg
Type: N/A
Width: N/A
Depth: N/A
Height: N/A
Height (in inclined position): N/A
Weight (net): N/A

Microtome Performance Specs

Specimen Feed: approx. 24 mm ±2 mm
Vertical Stroke: 70 mm ±1 mm
Large Standard Clamp: 55 x 50 x 30 mm
Super Cassette Clamp: 68 x 48 x 15 mm
Motorized Sectioning Speeds: N/A
In Manual Sectioning Mode: Approx. 40 µm (can be turned off)
In Motorized Sectioning Mode: N/A
Horizontal: ± 8°
Vertical: ± 8°
Range: 1 - 60 µm
Setting Values: 1 - 10 µm (in 1 µm increments)
10 - 20 µm (in 2 µm increments)
20 - 60 µm (in 5 µm increments)
Range: 10 µm, 30 µm
Setting Values: N/A

Additional Specifications

Handwheel Balance System:
Handwheel Lock / Brake: 2 Mechanical Locks
Safety Hand Wheel: N/A
Coarse Feed Wheel Turn Direction: User-Selectable - Clockwise or Counter-Clockwise
Type Standard
Waste Tray Volume 1400 ml
Rock Mode: - manual
Single Mode:
Continuous Mode:
Step Mode:
Program Mode:
Type: 2-in 1 for high and low profile blades
North-South Movement: ± 24 mm
East-West Movement: N/A
Lateral Displacement Function: via knife holder CE clamping top
Remaining Feed Indicator Visual
Section Counter
Section Thickness Totalizer
Memory Position
Special Spindle for Precise Semi-Thin Sectioning
Expanded Slow Speed Adjustment for Precise Semi-Thin Sectioning
Precise 3D Object Head Stop Position


Product Features

Customized Settings for Comfort and Efficiency

Using the new adjustable manual coarse feed wheel, comfortably advance or retract the specimen.


Save Room on your Workbench - Store Tools on Top of your Microtome

Our new models feature 40% more surface area on top of the microtome. You can store even more of your necessary tools - brush, blades, wipes, and more.

Prepare High Quality Non-Human Paraffin Sections for all of your Research Needs

The microtome is specially designed for serial cutting with the actively cooled RM CoolClamp and the low-temperature block for consistent slice thickness over multiple sections. Switch between high and low-profile blades even faster without changing blade holders by using the 2-in-1 Blade Holder.


Precision Orientation System

Always get back to the 0-position on the microtome. The precision orientation system allows you to precisely position your specimen prior to sectioning.

Force Balance System

The unique force balance system handles various block sizes as well as the RM CoolClamp, which minimizes the risk of injury from an unbalanced object head.


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Type Mechanical Semi-Motorized Motorized Motorized
Precision-Orientation System
Force Balance System
2-in-1 Blade Holder
Specimen Cooling Option with RM CoolClamp
Standard Waste Tray
Silent Retraction
Personalized Coarse Feed Wheel
Fast Homing
Memory Position
Electronic Brake
Special Spindle for Precise Semi-Thin Sectioning
Expanded Slow Speed Adjustment for Precise Semi-Thin Sectioning
Precise 3D Object Head Stop Position











Force Balance System

Silent Retraction

Coarse Feed Wheel Turn Direction

Frequently Asked Questions

HistoCore Microtomes

Does the new HistoCore RM antistatic tray fit on the older RM22xx series?

No – the microtome base plates of both series have different dimensions and are not compatible with each other.

How does the new antistatic waste tray reduce contamination?

The antistatic waste tray is made from resistant antistatic material to avoid debris sticking to the walls of the tray.

Is the new 2-in-1 blade holder compatible as a whole assembly with the older RM22xx series?

Yes – only in the combination blade holder and 2-in-1 blade holder.

Can we still use the backlighting with the new blade holder base for the 2-in-1 blade holder?

No – the 2-in-1 blade holder base does not have the cut-out for the backlighting.

Which accessories of the older RM22xx Series cannot be used with the HistoCore RMs anymore?

  1. Small section waste tray
  2. Large section waste tray
  3. Top tray – HistoCore RM top tray is 40% larger than the RM22xx series tray
  4. Cooling Device – too small to be placed on instrument top. However, it’s still good to place next to the instrument



What is the advantage of the personalized coarse feed wheel?

Convenience and ease-of-user – users can select their personal preference of coarse feed wheel turn direction. This feature is preserved from the RM22xx series, allowing users to trim at the high pace.

What is the advantage of “Fast homing”?

The return speed of the object head from front to home position has been reduced from 26 seconds (older series) to 13 seconds (new series). This accelerated speed helps to shorten the sectioning process each time the object head is returned to home position.

What is the advantage of the Memory Position?

When batch trimming and using the same height of blocks, Memory Position will help to accelerate the sectioning.

  1. First insert a new block
  2. Bring the block to the blade
  3. Set the Memo position (stored)
  4. Trim
  5. Remove block for re-cooling
  6. Press “Memo” – the object head returns to the set object change position
  7. Insert a new block – check position
  8. Trim again





Choose your option below, and then use the Contact Us link above to submit a quote request for your selection

Configuration 1 (149BIOR00C1)

  • Manual mechanical rotary microtome
  • Includes Standard Section Waste Tray
  • Top Tray
  • Precision orientation with quick clamping system for specimen clamps
  • Universal cassette clamp
  • Two-in-one blade holder E for high and low-profile blades with lateral displacement function (includes blade holder base)

Basic Instrument (14052158201)

  • Manual mechanical rotary microtome
  • Includes Standard Section Waste Tray
  • Top Tray
  • Completely customizable with a wide selection of accessories