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HistoCore AUTOCUT - Automated Rotary Microtome

149AUTO00C1, 14051956472

A Microtome Unlike any Other

Do you struggle to meet the needs of EVERY microtomist in your lab? Finally, there is a solution designed to give your users the freedom they desire: HistoCore AUTOCUT. The new generation of microtomes from Leica Biosystems is built upon our 145+ year heritage of market-leading microtome design. It allows users to select among automated, semi auto-automated, or manual sectioning modes based their personal preferences.

  • Every microtomist can use their prefrerred sectioning mode:
    • Automated: motorized push-button sectioning
    • Semi-automated: push-button specimen advance & retract
    • Manual: full control for those who love the art of microtomy
  • Maximize safety in the lab: The AUTOCUT improves on past automated models with an automatic electronic brake to minimize the risk of injury during operation.
  • Shorten cleaning time from minutes to seconds with the Antistatic Waste Tray.
Select a configuration


Product Specifications


Type: Motorized
Nominal Supply Voltage: 100 / 120 / 230 / 240 V AC
Nominal Frequency: 50/60 Hz
Maximum Power Consumption: 100 VA
Protection Class: I
Power Fuses: 2 x T 3.15 AL, 250V
Pollution Degree: 2
Overvoltage Category: II
Maximum Heat Emission: 340 J/s
Operating Temperature Range: +18°C to +35°C
Temperature Range During Storage: +5°C to +50°C
Relative Humidity During Operation: 20% to Max. 80% Non-Condensing
Relative Humidity During Storage: 10% to Max. 85% Non-Condensing

Dimensions & Weight

Width (including handwheel and coarse feed wheel): 477 mm
Depth (including waste tray): 620 mm
Height (without top tray): 295 mm
Weight (without accessories): Approx. 40 kg
Type: Separate control panel & in-housing integrated instrument control panel
Width: 119 mm
Depth: 193 mm
Height: 50 mm
Height (in inclined position): 81 mm
Weight (net): 0.6 kg

Microtome Performance Specs

Specimen Feed: approx. 24 mm ±1 mm
Vertical Stroke: 70 mm ±1 mm
Large Standard Clamp: 55 x 50 x 30 mm
Super Cassette Clamp: 68 x 48 x 15 mm
Motorized Sectioning Speeds: 0 - 420 mm/s ±10%
In Manual Sectioning Mode: 5 - 100 µm (in 5 µm increments); can be turned off
In Motorized Sectioning Mode: Speed-Dependent; can be turned off
Horizontal: ± 8°
Vertical: ± 8°
Range: 0.5 - 100 µm
Setting Values: 0.5 - 5 µm (in 0.5 µm increments)
5 - 20 µm (in 1 µm increments)
20 - 60 µm (in 5 µm increments)
60 - 100 µm (in 10 µm increments)
Range: 1 - 600 µm
Setting Values: 1 - 10 µm (in 1 µm increments)
10 - 20 µm (in 2 µm increments)
20 - 50 µm (in 5 µm increments)
50 - 100 µm (in 10 µm increments)
100 - 600 µm (in 50 µm increments)

Additional Specifications

Handwheel Balance System:
Handwheel Lock / Brake: 2 Mechanical Locks, 1 Electronic Brake
Safety Hand Wheel: Handle can be Centered
Coarse Feed Wheel Turn Direction: Clockwise or Counter-Clockwise
Type Anti-static
Waste Tray Volume 1400 ml
Rock Mode: - with activated retraction
Single Mode:
Continuous Mode:
Step Mode:
Program Mode:
Type: 2-in 1 for high and low profile blades
North-South Movement: ± 24 mm
East-West Movement: 3 Positions
Lateral Displacement Function: via knife holder CE clamping top
Remaining Feed Indicator Visual and Acoustical
Section Counter
Section Thickness Totalizer
Memory Position
Special Spindle for Precise Semi-Thin Sectioning
Expanded Slow Speed Adjustment for Precise Semi-Thin Sectioning
Precise 3D Object Head Stop Position


Product Features

Safety First with the Automatic Electronic Brake

As soon as you pause the automated sectioning function, the Electronic Brake kicks in immediately to return and hold the specimen in the safest position away from the blade. This helps to minimize injury to the operator when handling the specimen.

Safety First with the Automatic Electronic Brake
Antistatic Waste Tray (Brush Included)

Antistatic Waste Tray (Brush Included)

With the Antistatic Waste Tray, AUTOCUT helps you keep your workplace clean, efficient, and debris-free. The tray is made from antistatic material which prevents paraffin waste from sticking to the walls. It provides unmatched efficiency by reducing your cleaning time from minutes to seconds.

Put (Almost) Anything on Top of your Microtome!

Our new models feature 40% more surface area on top of the microtome (23.5cm W x 27.5cm L, vs. 21.7cm W x 21.2cm L on the RM22xx series) so you can store the tools you need for your job – brushes, blades, wipes, and more.

40% more Surface Area on Microtome Top Compared to older RM22xx Series

Precision-Orientation System

Always get back to a 0-position home on the microtome, regardless of how you (or another tech) have changed the instrument's orientation.

Force Balance System

Minimize the risk of injury to the operator or specimen by an unbalanced object head.


Quick Compare Chart


HistoCore BIOCUT

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Currently viewing

Type Mechanical Semi-Motorized Motorized
Precision-Orientation System
Force Balance System
2-in-1 Blade Holder
Specimen Cooling Option with RM CoolClamp
Antistatic Waste Tray
Silent Retraction
Personalized Coarse Feed Wheel
Fast Homing
Memory Position
Electronic Brake











Product Feature Demo Videos

Force Balance System

Electronic Brake

Frequently Asked Questions

HistoCore Microtomes

Does the new HistoCore RM antistatic tray fit on the older RM22xx series?

No – the microtome base plates of both series have different dimensions and are not compatible with each other.

How does the new antistatic waste tray reduce contamination?

The antistatic waste tray is made from resistant antistatic material to avoid debris sticking to the walls of the tray.

Is the new 2-in-1 blade holder compatible as a whole assembly with the older RM22xx series?

Yes – only in the combination blade holder and 2-in-1 blade holder.

Can we still use the backlighting with the new blade holder base for the 2-in-1 blade holder?

No – the 2-in-1 blade holder base does not have the cut-out for the backlighting.

Which accessories of the older RM22xx Series cannot be used with the HistoCore RMs anymore?

  1. Small section waste tray
  2. Large section waste tray
  3. Top tray – HistoCore RM top tray is 40% larger than the RM22xx series tray
  4. Cooling Device – too small to be placed on instrument top. However, it’s still good to place next to the instrument



What is the advantage of the personalized coarse feed wheel?

Convenience and ease-of-user – users can select their personal preference of coarse feed wheel turn direction. This feature is preserved from the RM22xx series, allowing users to trim at the high pace.

What is the advantage of “Fast homing”?

The return speed of the object head from front to home position has been reduced from 26 seconds (older series) to 13 seconds (new series). This accelerated speed helps to shorten the sectioning process each time the object head is returned to home position.

What is the advantage of the Memory Position?

When batch trimming and using the same height of blocks, Memory Position will help to accelerate the sectioning.

  1. First insert a new block
  2. Bring the block to the blade
  3. Set the Memo position (stored)
  4. Trim
  5. Remove block for re-cooling
  6. Press “Memo” – the object head returns to the set object change position
  7. Insert a new block – check position
  8. Trim again





Choose your option below, and then use the Contact Us link above to submit a quote request for your selection

Configuration 1 (149AUTO00C1)

  • Rotary microtome with Automated, Semi-Automated, and Manual Modes
  • Automatic Electronic Brake
  • Includes Antistatic Section Waste Tray
  • Top Tray
  • Precision orientation with quick clamping system for specimen clamps
  • Universal cassette clamp
  • Two-in-one blade holder E for high and low-profile blades with lateral displacement function (includes blade holder base)

Basic Instrument (14051956472)

  • Rotary microtome with Automated, Semi-Automated, and Manual Modes
  • Antistatic Section waste tray, top tray without specimen orientation or additional accessories.
  • Automatic Electronic Brake
  • Completely customizable with a wide selection of accessories