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  • HistoCore NANOCUT R Person Knife Holder GD
  • HistoCore NANOCUT R Hero Left Knife Holder E TC
  • Configuration for 3D Reconstruction with NANOCUT R
  • Stacking Technique for 3D Reconstruction
  • HistoCore NANOCUT R Hero Left Knife Holder GD
  • HistoCore NANOCUT R Person Knife Holder GD
  • HistoCore NANOCUT R Hero Left Knife Holder E TC
  • Configuration for 3D Reconstruction with NANOCUT R
  • Stacking Technique for 3D Reconstruction
  • HistoCore NANOCUT R Hero Left Knife Holder GD

HistoCore NANOCUT R - Automated Research & Special Applications Rotary Microtome


Discover New Breakthroughs with an Enhanced Level of Precision and Versatility

When your microtomy involves diverse samples in order to discover new breakthroughs in your research projects, then NANOCUT R is the optimal solution for you. The new generation of microtomes from Leica Biosystems is built upon our 145+ year heritage of market-leading microtome design. From biomedical research to industrial applications, NANOCUT R can cut virtually anything you put in front of it.

  • Cut sections that can be prepared for analysis in light microscopy and electron microscopy - down to 250nm (0.25µm, semi-thin).
  • Preserve sample integrity when performing semi-thin sectioning with the Special Spindle and expanded Slow Speed Adjustment.
  • Precisely stop the sample in the object head’s optimal position for photo-capture of the cut sample surface when running 3-dimensional reconstruction programs.*
Select a configuration

*Source for Featured 3D Reconstruction Content: IGBMC, PHENOMIN, iCS


Product Specifications


Type: Motorized
Nominal Supply Voltage: 100 / 120 / 230 / 240 V AC ±10%
Nominal Frequency: 50/60 Hz
Maximum Power Consumption: 100 VA
Protection Class: I
Power Fuses: 2 x T 3.15 A
Pollution Degree: 2
Overvoltage Category: II
Maximum Heat Emission: 340 J/s
Operating Temperature Range: +18°C to +35°C
Temperature Range During Storage: +5°C to +50°C
Relative Humidity During Operation: 20% to Max. 80% Non-Condensing
Relative Humidity During Storage: 10% to Max. 85% Non-Condensing

Dimensions & Weight

Width (including handwheel and coarse feed wheel): 415 mm
Depth (including waste tray): 620 mm
Height (without top tray): 295 mm
Weight (without accessories): Approx. 40 kg
Type: Separate control panel & in-housing integrated instrument control panel
Width: 119 mm
Depth: 193 mm
Height: 50 mm
Height (in inclined position): 81 mm
Weight (net): 0.6 kg

Microtome Performance Specs

Specimen Feed: approx. 24 mm ±2 mm
Vertical Stroke: 70 mm ±1 mm
Large Standard Clamp: 55 x 50 x 30 mm
Super Cassette Clamp: 68 x 48 x 15 mm
Motorized Sectioning Speeds: 0 - 195 mm/s ±10%
In Manual Sectioning Mode: 5 - 50 µm (in 5 µm increments); can be turned off
In Motorized Sectioning Mode: Speed-Dependent; can be turned off
Horizontal: ± 8°
Vertical: ± 8°
Range: 0.25 - 50 µm
Setting Values: 0.25 - 0.5 µm (in 0.25 µm increments)
0.5 - 5 µm (in 0.5 µm increments)
5 - 20 µm (in 1 µm increments)
20 - 50 µm (in 5 µm increments)
Range: 1 - 300 µm
Setting Values: 1 - 10 µm (in 1 µm increments)
10 - 20 µm (in 2 µm increments)
20 - 50 µm (in 5 µm increments)
50 - 100 µm (in 10 µm increments)
100 - 300 µm (in 50 µm increments)

Additional Specifications

Handwheel Balance System:
Handwheel Lock / Brake: 2 Mechanical Locks, 1 Electronic Brake
Safety Hand Wheel: Handle can be Centered
Type Antistatic
Waste Tray Volume 1400 ml
Rock Mode: - with activated retraction
Single Mode:
Continuous Mode:
Step Mode:
Program Mode:
Type: Semi-Thin Sectioning - Knife Holder GD
Resin Sectioning - Knife Holder NZ or Knife Holder E-TC
Paraffin Sectioning: 2-in-1 Blade Holder E
North-South Movement: ± 24 mm
East-West Movement: 3 Positions
Lateral Displacement Function: via knife holder CE clamping top
Remaining Feed Indicator Optical and Acoustical
Section Counter
Section Thickness Totalizer
Memory Position
Special Spindle for Precise Semi-Thin Sectioning
Expanded Slow Speed Adjustment for Precise Semi-Thin Sectioning
Precise 3D Object Head Stop Position


Product Features

Precise and Consistent Semi-Thin Sectioning

Avoid destruction of samples with the Special Spindle and expanded Slow Speed Adjustment capabilities which allow you to produce consistent semi-thin sections down to 250nm.

NANOCUT Supports Special Accessories such as Diamond Knives
HistoCore NANOCUT - Discover New Breakthroughs

Tackle the Toughest Materials with a Wide Range of Accessories

Leverage a wide range of accessories available to the NANOCUT R, including holders for disposable steel and tungsten carbide blades, reusable knives, and a special holder for glass and diamond knives.

Antistatic Waste Tray (Brush Included)

With the Antistatic Waste tray, NANOCUT R helps you keep your workplace clean, efficient, and debris-free. The tray is made from antistatic material which prevents waste from sticking to the walls. It provides unmatched efficiency by taking your cleaning time down from minutes to seconds.

Antistatic Waste Tray (Brush Included)

Precision-Orientation System

Always get back to a 0-position home on the microtome, regardless of how you (or another tech) have changed the instrument's orientation.

Force Balance System

Eliminates the risk of injury to the operator or specimen by an unbalanced object head.


Quick Compare Chart


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Currently viewing

Type Mechanical Semi-Motorized Motorized Motorized
Precision-Orientation System
Force Balance System
2-in-1 Blade Holder
Specimen Cooling Option with RM CoolCut
Antistatic Waste Tray - optional - optional - optional - standard
Silent Retraction
Personalized Coarse Feed Wheel
Fast Homing
Memory Position
Electronic Brake
Special Spindle for Precise Semi-Thin Sectioning
Expanded Slow Speed Adjustment for Precise Semi-Thin Sectioning
Precise 3D Object Head Stop Position



Product Feature Demo Videos

Force Balance System

Electronic Brake

Nanocut R instrument

Frequently Asked Questions

HistoCore Microtomes

Does the new HistoCore RM antistatic tray fit on the older RM22xx series?

No – the microtome base plates of both series have different dimensions and are not compatible with each other.

How does the new antistatic waste tray reduce contamination?

The antistatic waste tray is made from resistant antistatic material to avoid debris sticking to the walls of the tray.

Is the new 2-in-1 blade holder compatible as a whole assembly with the older RM22xx series?

Yes – only in the combination blade holder and 2-in-1 blade holder.

Can we still use the backlighting with the new blade holder base for the 2-in-1 blade holder?

No – the 2-in-1 blade holder base does not have the cut-out for the backlighting.

Which accessories of the older RM22xx Series cannot be used with the HistoCore RMs anymore?

  1. Small section waste tray
  2. Large section waste tray
  3. Top tray – HistoCore RM top tray is 40% larger than the RM22xx series tray
  4. Cooling Device – too small to be placed on instrument top. However, it’s still good to place next to the instrument



What is the advantage of the personalized coarse feed wheel?

Convenience and ease-of-user – users can select their personal preference of coarse feed wheel turn direction. This feature is preserved from the RM22xx series, allowing users to trim at the high pace.

What is the advantage of “Fast homing”?

The return speed of the object head from front to home position has been reduced from 26 seconds (older series) to 13 seconds (new series). This accelerated speed helps to shorten the sectioning process each time the object head is returned to home position.

What is the advantage of the Memory Position?

When batch trimming and using the same height of blocks, Memory Position will help to accelerate the sectioning.

  1. First insert a new block
  2. Bring the block to the blade
  3. Set the Memo position (stored)
  4. Trim
  5. Remove block for re-cooling
  6. Press “Memo” – the object head returns to the set object change position
  7. Insert a new block – check position
  8. Trim again





Choose your option below, and then use the Contact Us link above to submit a quote request for your selection

NANOCUT R (14052458261)

  • Rotary microtome with Automated and Manual Modes
  • Automatic Electronic Brake
  • Special Spindle and expanded slow speed adjustment capabilities allows accurate specimen feeding for semi-thin sections of 250 nm
  • Precise 3D object head stop position allows for taking pictures of the cut specimen surface after each section to enable 3D reconstruction
  • Includes Antistatic Section Waste Tray


Disposable Blades

Code Name Show all details Qty
14035843499 High-profile disp.blades DB80HS (1x10)
14035843490 High-profile disp.blades DB80HS (1x50)
14035843491 Hig-profile disp.blades DB80HS (10x50)
14035843498 Low-profile disp.blades DB80LS (1x10)
14035843488 Low-profile disp.blades DB80LS (1x50)
14035843489 Low-profile disp.blades DB80LS (10x50)
14035843502 Low profile disp.blades DB80LX (1x10)
14035843496 Low-profile disp.blades DB80LX (1x50)
14035843497 Low-profile disp.blades DB80LX (10x50)
14035838926 High-profile disposable blades 818(1x50)
14035838383 High-profile disposable blades818(10x50)
14035838925 Low-profile disposable blades 819 (1x50)
14035838382 Low-profile disposable blades 819(10x50)
14021626379 Disposable blades TC-65 1Package=5Blades

Reusable Knives

Code Name Show all details Qty
14021607100 Knife, 16 cm long, profile c steel assy
14021607132 Knife, 16 cm long, profile d steel assy
14021604813 Knife 16 cm d TC, assy
14021604206 Knife 16 cm c TC assy
14021311140 Knife Case- small
14021311141 Knife Case large


Code Name Show all details Qty
14034040859 Safety gloves size S
14034029011 Safety gloves size M


Specimen Orientation and Quick Clamping System

Code Name Show all details Qty
14050237717 Fine-directional fixture for spec. clamp
14050238949 Directional fixture for spec. clamp
14050238160 Ridgid fixture for spec. clamp
14050237718 Quick Clamping System

Specimen Clamps

Code Name Show all details Qty
14050246573 RM-CoolClamp
14050229969 Segment arc with adapter
14050240314 segment arc with adapter, direct
14050229968 EM specimen holder fixture
14035610868 EM universal specimen holder
14035510405 EM flat specimen holder
14035610869 Special wrench for EM holders
14050237999 Universal cassette clamp
14050238005 Standard specimen clamp 50x55 mm
14050237998 Standard specimen clamp 40x40 mm
14050238967 Super mega cassette clamp
14050238002 Round specimen holder w/3 inserts
14050238000 V-insert
14040209307 Foil clamp

Blade Holders and Blade Holder Base

Code Name Show all details Qty
14050255546 Blade Holder Base
14050254497 2-in-1 Blade holder E

Knife Holders and Knife Holder Base

Code Name Show all details Qty
14050239052 Knife holder GD
14050237962 Knife holder base
14050237993 Knife holder N
14050237994 Knife holder NZ
14050238961 Knife holder E w/trough low-profile
14050237997 Knife Holder E-TC

Section Waste Tray

Code Name Show all details Qty
14051856458 Standard waste tray
14051756237 Anti-static waste tray

Other Accessories

Code Name Show all details Qty
14050238719 Backlighting
14051756261 Top tray
14050240580 Universal microscope carrier
14050242790 Magnifier
14600004826 LED 1000 Hi-Power spots, 2-arms
14600004825 LED 1000 control unit
14018340426 Leica-brush with Magnet
14050238257 Foot switch for rotary microtomes
14050238463 Microscope carrier w/LED Hi-Power spots