Fast Forward to Next Generation Imaging - The Leica Biosystems Solution Bringing Your Digital Pathology to the Next Level.

Hello, and welcome to the Aperio GT450 DX display today. Today is only the start of your journey into Aperio GT450 DX. The whole system, I'll go through scanner, SAM server and SAM software, as well as the DX viewing stations.

The Aperio GT450 DX system can be used for MDMs, archiving, primary diagnosis, and a range of other applications. The GT450 DX system is CE IVD registered for primary diagnosis.

First up, we're going to show you the Aperio GT450 DX scanner. On the left-hand side, we have a color-coded legend, which shows us exactly what is happening currently on the scanner.

Each rack in the carousel will be given a color based on what is currently happening with that rack. As you can see, some racks are green, which means that they are currently complete. Some racks are gray, which means that there are currently no racks in those positions. Some racks show light blue, meaning that they are currently waiting to scan. And our current scanning rack is flashing blue. On the right-hand side of the screen, we have the rack view.

The rack view shows us a colored line for each slide in the rack. This rack has 13 slides, and we're currently scanning the last slide. Each one of the slides are color-coded based on that specific slide and the actions taken with that slide. The green icon right next to the slide means that the scan is completed and that the image passed QC, and the image was saved to the specified image location.

During scanning, the currently scanning rack is removed from the carousel so the carousel can rotate freely. Before rotating, the carousel will show flashing lights and a notification on the screen to tell you when it's going to move.

The scanned rack is placed back into the carousel, and the next rack to be scanned will be taken from the carousel so that more racks can be placed on the machine and slides can be removed.

While we are on the carousel or home view, we can see the carousel and all of the slide racks on it
currently. If we want to remove a rack that is not in the front six positions, we can tap a rack. But for that, we will need to log in.

So if we tap a rack, it will ask us for our PIN. We can put in our PIN. The PIN is supplied or can be changed by your IT department with the use of the scanner administration management server software.

Now that we're logged in, we can select a rack that's not part of the front six, and we can tap Rotate. If the rack was part of the front six cassettes, we can remove that rack at any time. You can see we have a countdown to show us when we can remove that rack. We will take the rack, the countdown will restart, and the carousel will rotate to give you the most positions available to add new racks into the carousel.

The Aperio GT450 DX can use racks from both the Leica HistoCore SPECTRA stainer, as well as the Sakura stainer. The Sakura stainer racks have a capacity of 20 slides, whereas the Leica HistoCore SPECTRA racks can take up to 30 slides. If we fill all 15 carousel rack positions with Leica HistoCore SPECTRA racks, we have a capacity of 450 slides.

So currently, we have selected an empty rack position. If we touch the rack that is currently scanning, it only has one slide. If there were more slides, they would be light blue, and they will show Waiting to Scan.

In the rack view, we see the rack and the current slide that's being scanned. In our slide view, we can see the slide that's just been scanned.

The GT450 DX has a 99.5% accurate tissue finder algorithm that excludes fingerprints and dust to create an area just bigger than your tissue to scan. If the tissue finder does happen to miss your tissue, you can tap the Scan Entire Slide button, which replaces the image with a whole slide scan.

In our rack order view, we can see which racks are currently scanning and which racks are next to scan. If we enter another rack into the system, their rack order will be next after rack number two. If we want to set a priority, we can tap the rack, and we can tap Priority.

We can either eject the active rack and scan the priority rack immediately, after which it would return to the rack it's currently scanning and finish the scan.

If we say No, the current rack will finish scanning, and then rack number two, which is now our priority rack, is first priority. If we create another priority rack, they will be second priority after rack number two.

On slide three and slide 13, we have a slide warning. To see what these warnings are, we can go to Slide view, and we can scroll to slide three. On this slide, we can see the error code, which is the reason for the error.

In this case, an image quality error. We can tap the error to remove the error from the slide so we can see our tissue. We can tap the slide again to reveal the error back on the slide.

If it is necessary, we can tap the Scan Entire Slide button and confirm that we would like to scan the whole slide. For slide 13, we can tap the Slide view and move to slide 13, which also shows an image quality error. We can see that the mountant at the top of the slide was recognized as tissue.

We can see the error in this case is that the tissue finder algorithm included a part of the mountant at the top of the coverslip as tissue. The tissue was still selected, and based on this, we can move on knowing that the image quality error came about because of the mountant at the top of the slide. To reduce this error from occurring again, we would make sure that we don't use excessive amounts of mountant.

As part of the SAM service software, there is a timeout associated with each instrument for PIN login. If we do not touch the touchscreen within that time period, the system will automatically log out the user.

In the SAM service software, there is a pin timeout value. That value can be changed independently for every single scanner that you have on that SAM server.

To be able to access our top menus, as well as rotate or create a priority rack, we will need to log in. To log in, we can tap any of the functions on the screen and enter our PIN.

Now that we're logged back in, we can go to our statistics screen. In our statistics screen, we will see statistics for the last seven days, the last 12 months, and the lifetime by year of the instrument.

On the right-hand side of the screen, we can see the number of slides scanned, the average scan time per slide, the average size of slides scanned, the normalized 15 by 15-millimeter scan time, and lastly, the average file size.

This instrument is a pre-production model and does not show our average file size. This allows lab managers to forecast usage, data created, and time necessary for scanning.

Our next screen is our maintenance screen. On the maintenance screen, we have information about the scanner. We have a Shutdown button, a Restart button, as well as maintenance videos.

Daily maintenance for the Aperio GT450 DX includes restarting the scanner. Six-monthly maintenance for the scanner includes cleaning the objective and collar, cleaning the stage slide tray, cleaning the carousel, cleaning the slide racks, cleaning the fan filter on the rear of the instrument, cleaning the touchscreen, and cleaning the scanner cover.

Yearly maintenance includes an annual visit from our service team for preventative maintenance. Some of our maintenance tasks and our recovery tasks are clearly shown in easy-to-follow video tutorials.

In our Help menu, you can see a three-minute getting started video, which shows you all the functions and parts of the instrument. We also have a quick reference guide, which is also available from the website. This is a scrollable PDF document. And we also have some training videos. The training videos are short-form information videos to show you exactly how to perform an action. Returning to the carousel window.

In the carousel window or home screen, we can see all of our green racks, meaning that they are complete, as well as our orange rack, which means that the rack is complete, but it has a warning. On rack 14 with the warning, we can see that slide 13 has that slide image warning. As we can see on the screen right now, all of our racks have been completed.

If we want to remove any of the racks that are not within the six front positions in the carousel, we can tap the rack, and we can tap Rotate. Once the rack is out the front, we have a couple of seconds to remove the rack, and the carousel will again rotate to show us the most empty stations out the front so we can add more racks.

Now, let us look at the SAM or Scanner Administration Manager software. Once we log into the SAM server, we can see the scanners associated with this server. We can also see users created who have access to the SAM server. When we create a user for the SAM server, we can give them either a lab admin role or an operator role.

The difference between the two being that our operator can view most of the functions, whereas our admin role can edit functions as well as view extra functions of the SAM server. Going back to our scanners, we can go to the system information of the current scanner that we have here in the building.

The system information page will show us the same information that is on the screen of the GT450 DX. We also see the same scanner statistics. Additionally, to the GT450 DX scanner, we also have a System Settings page.

As part of the Scanner Administration Manager, we need to be able to look at event logs as well as system information. In our event logs, we can download logs and send them to support for evaluation.

We also have configuration settings. This is where your IT department can assign PINs for the scanners, as well as associate storage locations for your images. The Scanner Administration Management server can be connected to a maximum of four Aperio GT450 DX scanners.

Each one of these servers and scanners can be managed by your IT department through this OS-agnostic web page application.