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Naveni® Kits for BOND RX Fully Automated Research Stainer by Leica Biosystems

Navinci is a Swedish biotechnology company specializing in developing innovative solutions for studying proteins, protein-protein interactions, and post-translationally modified proteins in cells and tissues. With a focus and strong legacy in developing in situ proximity ligation assay technology, Navinci has established itself as a center of excellence in the spatial biology field and has a broad portfolio of products that help academic researchers and biopharma study the protein interplay in depth.

Features and Benefits of Your Technology

Automated detection of protein interplay in situ

  • Cutting-edge Technology: Incorporates proprietary Naveni® in situ Proximity Ligation Technology for precise detection of protein interactions and post-translational modifications in situ.
  • Automation: Integrates with the BOND RX research staining platform, enhancing precision and efficiency in research workflows.
  • Flexibility: Offers a range of assays tailored to specific research needs, including PD1/PD-L1 interactions.
  • Spatial Insights: Provides detailed spatial insights into protein function and relationships within the tissue microenvironment, illuminating function within the spatial context.
  • Enhanced Reproducibility: Facilitates reproducible results through standardized, automated workflows, minimizing variability and increasing reliability.
  • Timesaving: By streamlining assay preparation and execution of high-throughput data acquisition, it reduces hands-on time and increases overall research productivity.

Illuminating Function in Spatial Proteomics

  • Enhanced Research Insights: Clear visualization of protein interactions and post-translational modifications within the tissue microenvironment enables researchers to gain deeper insights into spatial biology and protein function.
  • Improved Efficiency: Automation of assay workflows reduces hands-on time and streamlines processes, allowing researchers to focus more on analysis and interpretation.
  • Increased Reproducibility: Standardized, automated workflows minimize variability and increase the reliability of research results, ensuring consistent outcomes across experiments.
  • Accelerated Discoveries: Naveni BOND RX products empower researchers to accelerate discoveries and advance scientific knowledge in their fields by providing detailed spatial insights and facilitating reproducible results.
  • Enhanced Productivity: Time-saving automation and streamlined workflows maximize research productivity, enabling researchers to achieve more in less time and with fewer resources.

Research Focus

Precise Visualization of PD1/PD-L1 Interactions using Naveni PD1/PD-L1 BOND RX

The Naveni® BOND RX products offer a comprehensive solution for studying PD1/PD-L1 interactions within the tissue microenvironment. With precise visualization capabilities, researchers can gain deeper insights into the dynamics of immune checkpoint pathways, facilitating the development of targeted immunotherapies for cancer treatment.

Two examples of staining of PD1/PD-L1 interaction in Squamous cell carcinoma, head and neck cancer.

Investigating Protein-Protein Interactions

Naveni® BOND RX products enable researchers to explore complex protein-protein interactions with high precision and accuracy using their own primary antibodies. By visualizing these interactions within the spatial context of cells and tissues, researchers can unravel intricate signaling networks and uncover novel therapeutic targets for various diseases.

An example is the interactions between CD8 and MHC-I. Understanding these interactions is vital for elucidating the role of cytotoxic T cells in immune surveillance and their involvement in diseases such as cancer and autoimmune disorders.

Staining of CD8/MHCI interaction in breast cancer using NaveniBright BOND RX HRP (A, B positive signals, C negative control)

Understanding Protein Function and Signaling Pathways

With Naveni® BOND RX products, researchers can investigate protein function and signaling events within the tissue microenvironment, shedding light on key biological processes and uncovering new avenues for therapeutic intervention. An example is the dynamic interplay between E-Cadherin and Beta-catenin. Providing insights into cell adhesion and signaling pathways is crucial for understanding tissue organization and the progression of various diseases, including carcinoid tumors.

Staining of E cadherin/Beta catenin interaction in TMA, A) Normal colon, B) Signet-ring cell carcinoma, C) Carcinoid tumor D) Adrenal gland (negative control) using NaveniBright BOND RX HRP

Meet Our People


Hampus Elofsson

R&D Project lead

Hampus Elofsson leads the effort to fully automate Navinci’s next-generation in situ proximity ligation assays, with the vision that Navinci’s assays should work with minimal effort from the customer and still maintain the same high quality, no matter where in the world the technology is used.


Doroteya Raykova, PhD

Application Scientist

Doroteya Raykova is an expert in method development and assays for in situ detection of protein-protein interactions and a passionate reader and writer of scientific texts. Her mission is to ensure that the Naveni® technology reaches those whose research can benefit from it, provide technical expertise, and help with setting up and troubleshooting.


Agata Zieba-Wicher, PhD

Chief Product and Science Officer

Agata Wicher leads in spatial proteomics, overseeing product development and scientific affairs. Her work bridges scientific research with product innovation, aligning with business strategies for market relevance and industry advancement.

Fully automated in situ detection of protein-protein interactions in tissue


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For Research Use Only. Not for use in diagnostic procedures.