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Delivering on the Promise of Liquid Biopsy


The potential for non-invasive tests that provide equivalent research and diagnostic value as can be obtained from tissue biopsies is real, but not yet realized. Tissue biopsies allow for identification, phenotyping and molecular analysis of cancer and associated cells. The RareCyte platform has been designed to reflect tissue analyses in the identification, multi-parametric characterization and single cell molecular interrogation of rare cells in liquid biopsies and other sample types. Applications to be presented include genomic assessment of heterogeneity in individual breast cancer circulating tumor cells (CTCs) at multiple time points during treatment, development of a Companion Diagnostics-type assay to identify the presence of a drug target on CTCs, and identification of rare antigenspecific T cells. These examples demonstrate progress toward the fulfilling the promise of liquid biopsy.

Learning Objectives:

  1. To understand how rare cell analysis, including “liquid biopsy”, can be incorporated into diagnostic pathology to extract clinically important information.
  2. To understand the value of phenotypic and molecular characterization of individual rare cells within liquid biopsies and other specimens.

Eric Kaldjian is Chief Medical Officer at RareCyte. He trained in anatomic pathology at the University of Michigan and subsequently at the National Cancer Institute. His pharmaceutical experience at Hoffmann- La Roche and at Parke-Davis/Pfizer encompassed discovery research through full clinical development positions with a focus on translational medicine. He has directed clinical genomics programs at Gene Logic, was Chief Scientific Officer at Transgenomic, and was Medical Director for Companion Diagnostics at Ventana Medical Systems before joining RareCyte, where he oversees scientific and medical applications of its rare cell detection technology. He is an associate member of the BioInterfaces Institute at the University of Michigan.

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