15 result(s) for 'CD4'
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Antigen Background
The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes and at a lower level on monocytes and germinal center macrophages. Most cases of cutaneous T cell lymphoma, including mycosis fungoides, express the CD4 antigen and HTLV-1 associated adult T cell leukemia/lymphoma is...
DESCRIPTION: Chromogenic multiplex IHC kit for BOND RX - human CD4, CD8, PanCK
SIZE: 10 slides
PRODUCT OVERVIEW: Kit for chromogenic multiplex IHC staining of 10 slides plus a single negative control slide on the BOND RX with V7.0 software.
1° Antibody
Clone
1° Tag
2° Antibody
Chromogen
CD4
EPR6855
UT014
Anti-UT014-HRP
Leica Blue
CD8
EPR10640(2)
UT015
Anti-UT015-AP
Leica Refine Red
PanCK
AE1/AE3
UT016
Anti-UT016-HRP
Yellow
Leica Refin...
DESCRIPTION: Kit for fluorescent multiplex IHC staining of human CD3, CD4, CD8, FoxP3, detection with 490, 550, 650, 750 nm fluors
SIZE: 5 slides
PRODUCT OVERVIEW: All components required to stain 5 multiplex slides plus a single negative control slide with simple two-step protocol.
1° Antibody
Clone
1° Tag
2° Antibody
2° Fluor
CD3
CAL57
UT016
Anti-UT016
CL650
CD4
EPR6855
UT019
Anti-UT019
CL750
CD8
EPR10640(2)
UT015
Anti-UT015
CL490
Fo...
DESCRIPTION: Kit for fluorescent multiplex IHC staining of human CD3, CD4, CD8, CD20, detection with 490, 550, 650, 750 nm fluors
SIZE: 5 slides
PRODUCT OVERVIEW: All components required to stain 5 multiplex slides plus a single negative control slide with simple two-step protocol.
1° Antibody
Clone
1° Tag
2° Antibody
2° Fluor
CD3
CAL57
UT016
Anti-UT016
CL650
CD4
EPR6855
UT014
Anti-UT014
CL550
CD8
EPR10640(2)
UT015
Anti-UT015
CL490
CD2...
Antigen Background
The CD45RO molecule, a 180 kD isoform of CD45, is reported to be expressed on 48% of peripheral blood T lymphocytes, 37% of CD4 positive lymphocytes, 80% of thymocytes and on the majority of T cell malignancies. Monocytes and granulocytes show surface expression of the antigen whereas tissue macrophages exhibit cytoplasmic expression.
Disclaimer
CD45RO is recommended for the detection of specific antigens of interest in normal ...
DESCRIPTION: Kit for fluorescent multiplex IHC staining of human CD4, CD8, FoxP3, PD-1, detection with 490, 550, 650, 750 nm fluors
SIZE: 5 slides
PRODUCT OVERVIEW: All components required to stain 5 multiplex slides plus a single negative control slide with simple two-step protocol.
1° Antibody
Clone
1° Tag
2° Antibody
2° Fluor
CD4
EPR6855
UT019
Anti-UT019
CL750
CD8
EPR10640(2)
UT015
Anti-UT015
CL490
FoxP3
1054C
UT014
Anti-UT014
CL550
...
Antigen Background
The CD45 antigen (leukocyte common antigen) is a family of five or more high molecular weight glycoproteins present on the surface of the majority of the human leukocytes (including lymphocytes, monocytes and eosinophils) but absent from erythrocytes and platelets. Various isoforms of CD45 are generated by alternative splicing of three exons. Expression of CD45 is necessary for signaling through the T cell receptor.
Disclaimer
...
Antigen Background
The CD43 antigen is expressed on the membrane and in the cytoplasm of T cells and cells of myeloid lineage. The molecule itself exhibits molecular weight heterogeneity with bands of 90 to 140 kD observed on SDS-PAGE between different cell lines. Cells expressing the CD43 antigen are reported to include normal and neoplastic T cells. A small proportion of B cell chronic leukemias and diffuse large B cell lymphomas are also repor...
Antigen BackgroundCTLA-4, T-cell co-receptor cytotoxic T-cell antigen-4 (CTLA-4, CD152) is a critical inhibitory regulator of T-cell immunity. CTLA-4 is expressed almost exclusively on CD4+ and CD8+ T-cells and is crucial in the maintenance of T-cell homeostasis. Expression is induced on activated T-cells, with marginal expression on resting cells. The role of CTLA-4 in regulation of T-cell activity in the tumour microenvironment indicates a pote...