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Difficult Blocks and Reprocessing

What To Do When Your Block Won’t Section

From time to time, in all histopathology laboratories, paraffin blocks will be encountered that are difficult or even impossible to section. This book provides guidance on how to deal with these difficult blocks to get the best possible section, and how to identify and avoid a repeat of underlying causes.


Part 1: The initial assessment
Why is my block difficult or impossible to cut?

Part 2: Getting more information
Examples of typical problems and their causes

Part 3: Detailed Solutions
Detailed solutions for difficult blocks

Part 4: Root Causes
The root cause of processing problems and their prevention

Part 5: Validation
How to validate a reprocessing method

Part 6: Appendix
Reprocessing decision trees