Characterization of the Pancreatic Tumor Microenvironment using Novel Quantitative Multiplex DPS
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease associated with poor outcomes. So far, the factors and pathways underlying patient survival in PDAC are unknown. However, the location, number, and characterization of immune cells that infiltrate PDAC tissue provide crucial information.
In this webinar, Dr. Dana Adel Mustafa, assistant professor and group leader of the Tumor Immuno-Pathology (TIP) Laboratory at Erasmus University Medical Centre, shares how using the GeoMx Digital Spatial Profiler (DSP) to measure PDAC tissue samples can reveal the key immune-related players that drive survival in PDAC patients. Mustafa explains how this technology enabled high-plex proteomic analysis of formalin-fixed, paraffin-embedded samples with spatial resolution. Mustafa also shares that higher B cell infiltration in PDAC tissue samples is associated with higher infiltration of T cells and higher antigen presentation, resulting in better prognoses.
- Learn how to extract the maximum information using the minimum amount of samples
- Understand why we need more than just numbers to tell the whole story
- Appreciate how precise tissue navigation leads to precise medicine
For the use of any product, the applicable product documentation, including information guides, inserts and operation manuals should be consulted. Leica Biosystems and the editors hereby disclaim any liability arising directly or indirectly from the use of the content, including from any drugs, devices, techniques or procedures described in the content.
Copyright © 2022 Leica Biosystems division of Leica Microsystems, Inc. and its Leica Biosystems affiliates. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH.