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Articles by thought leaders across the fields of Histology, Anatomic Pathology and cancer diagnostics.

  • YunLu Zou ,
    PhD, Technical Lead Engineer – Optical Systems at Leica Biosystems
  • Lance Mikus ,
    MBA, Director of Product Management - Image Capture Systems at Leica Biosystems

Leica Biosystems digital pathology engineers realize a breakthrough to real time focusing (RTF), achieving extremely high-speed line scanning at 40x magnification.

Brain damage from football, improvised explosive devices, and childhood falls has spurred a surge of funding for research on impact brain damage.

Fixation is a critical step in the preparation of histological sections. If it is not carried out under optimal conditions or if fixation is delayed, a tissue specimen can be irreversibly damaged. No matter how much care is subsequently taken in tissue...

Healthcare providers face seemingly contradictory demands: reduce costs, provide an efficient service to more patients, and improve quality of care. For Anatomical Pathology laboratories, automation and connectivity make it possible to achieve all three goals.

Varying the approach angle in stereotaxic surgery can overcome the conflict between positional accuracy and interpretability. Fortunately, modern computer controlled stereotaxic instruments make this possible.

As well as formaldehyde and glutaraldehyde, discussed previously, a number of other reagents have been used for fixation, sometimes in simple solution but often combined with other agents in the form of compound fixatives. The more important of these are...

Neuroscience researchers usually need to see slices of whole brain in order to determine the location in brain of detail they are viewing under the microscope.

This second part of the Fixation and Fixatives series covers the factors that influence the rate and effectiveness of tissue fixation as well as looking at two common fixatives: formaldehyde (histology) and glutaraldehyde (ultrastructural electron microscopy...

Sample tracking systems help reduce misdiagnosis by positively identifying patient tissue throughout the diagnostic process.

The instrument for moving a probe to a given coordinate in space – inside the brain – is a stereotaxic instrument.

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