Characterizing the Tumor Microenvironment through Immunophenotyping and Spatial Biology using Ultivue 8-plex Immunofluorescence Technology on the BOND RX Research Stainer
Multiplex immunofluorescence (mIF) assays offer the advantage of preserving the architectural features of the tumor microenvironment and revealing the spatial relationships between tumor cells and immune cells that are present.
Using custom-designed Ultivue 8-plex kits on the BOND RX system by Leica Biosystems, it enables the definition of the T cell phenotypes spatially and quantitively. This is especially important in treatment response monitoring and TME infiltration assessment in immunotherapy clinical programs at Adaptimmune where next generation SPEAR-T cell have been developed using Adaptimmune’s affinity-enhanced tumor antigen targeting TCR technology.
For Research Use Only. Not for use in diagnostic procedures.
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