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- Histology Solutions
  - Histology Solutions
    - Histology Solutions
      
      Fewer resources, more to do, and less time to get work done. While we can’t eliminate these pressures, we can help you make the most of each minute, meet your metrics, and consistently deliver slides on-time.
  - Tissue Processors
    - Tissue Processors
      
      We know one size does not fit all. Our broad range of tissue processors means you can choose the right instrument for your laboratory's space, throughput, and workflow needs.
  - Embedding Centers
    - - HistoCore Arcadia - Embedding Center
      - HistoCore Arcadia C - Cold Plate
      - HistoCore Arcadia H - Embedding Station
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    - Tissue Embedding Centers
      
      Optimal tissue embedding is essential for smooth sectioning and ribboning.  Intelligent automation for precise temperature control coupled with flexible, ergonomic configuration enable efficient workflow and maximized productivity.
  - Microtomes
    - - HistoCore AUTOCUT
      - HistoCore MULTICUT
    - Clinical Microtomes
      
      The choice of Clinical or Research Microtomes from Leica Biosystems gives the precision, control, and comfort needed to get the best possible section from every block, every day.
  - Cryostats
    - Cryostats
      
      In surgery every moment matters. Intraoperative consultations require rapid responses to surgical staff. Safely deliver consistent, quality frozen sections - fast.
  - Slide Stainers & Coverslippers
    - HistoCore SPECTRA Workstation
    - Leica ST5010 Autostainer XL
    - Leica CV5030 - Fully Automated Glass Coverslipper
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    - Slide Stainers & Coverslippers
      
      Life-changing diagnoses for every patient reside in every slide. Consistently deliver the high-quality staining your department demands with integrated stains, stainers and expert advice.
  - Specimen Identification
    - Leica IP C - Automated Inkjet Printer for Tissue Cassettes
    - Leica IP S -Automated Inkjet Printer for Microscope Slides
    - View All
    - Specimen Identification
      
      Confidence each patient is getting the right diagnostic report comes through ensuring chain of custody from sample, to slide, to diagnosis.  Track every specimen in your laboratory with tailored labeling to reduce errors and increase patient safety.
  - View All
- Histology Consumables
  - Histology Consumables
    - Consumables
    - Ancillaries
    - VIEW ALL
    - Histology Consumables
      
      Improve quality, reduce errors, and save time with dedicated plug and play consumables. From glass slides and coverslips to wax and bulk reagents, smooth running of any laboratory depends on a consistent supply of high-quality consumables.
  - Consumables
    - Histology Consumables
      
      Improve quality, reduce errors, and save time with dedicated plug and play consumables. From glass slides and coverslips to wax and bulk reagents, smooth running of any laboratory depends on a consistent supply of high-quality consumables.
  - Ancillaries
    - Autopsy
    - Dissection
    - Cytology Products
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    - Histology Consumables
      
      Improve quality, reduce errors, and save time with dedicated plug and play consumables. From glass slides and coverslips to wax and bulk reagents, smooth running of any laboratory depends on a consistent supply of high-quality consumables.
  - View All
- IHC & ISH
  - IHC & ISH
    - IHC & ISH
      
      Whether delivering clinical diagnostics or the next research breakthrough, every moment matters. There is constant pressure to quickly produce reliable results. Meet the challenge with solutions engineered to address today’s needs and tomorrow’s opportunities.
  - BOND IHC-ISH Instruments & Solutions
    - - BOND RXᵐ - Compact Research Stainer
      - View All
    - BOND IHC-ISH Instruments & Solutions
      
      Every BOND system is complete, automated, and engineered for speed, reliability, and accuracy, with each configuration tailored to address specific diagnostic or discovery challenges.
  - IHC Primary Antibodies
    - IHC Primary Antibodies
      
      Create high-quality IHC slides with a complete solution of antibodies, ancillary reagents, and detection systems. Developed in-house with 20+ years of experience, these robust antibodies are optimized for automated and manual applications.
  - Detection Systems
    - BOND Polymer Refine Detection
    - BOND Polymer Refine Red Detection
    - ChromoPlex 1 Dual Detection for BOND
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    - Detection Systems
      
      Reliably produce consistent staining with BOND automated detection systems: complete IHC-ISH staining solutions including Compact Polymer^TM detection, ancillary reagents, and consumables for single, dual, and multiplex staining.
  - Molecular Solutions
    - ThermoBrite - ISH/FISH Slide Denaturation/Hybridization Instrument
    - ThermoBrite Elite - Fully Integrated, Automatic ISH/FISH Slide Processing System
    - Kreatech FISH Probes| Leica Biosystems
    - ISH Probes - Molecular Pathology
    - Molecular Solutions
      
      A comprehensive range of probes, detection, ancillaries, and instruments for automated or manual ISH detection in fluorescence and brightfield applications.
  - Ancillaries & Consumables
    - BOND Epitope Retrieval Solution 1
    - BOND Epitope Retrieval Solution 2
    - Dewax Solution
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    - Ancillaries & Consumables
      
      A comprehensive range of high-quality ancillary reagents and consumables for IHC and ISH applications, including epitope retrieval solutions, pretreatments, detection components, and wash buffers, for automated or manual use.
  - Companion Diagnostics
    - Learn More
    - Companion Diagnostics: Cutting Edge Collaboration
      
      Leica Biosystems global Companion Diagnostics team collaborates with biopharmaceutical companies to develop and commercialize solutions that could identify patients likely to benefit from our partners’ emerging therapies.
  - OEM Reagent Partnerships
    - Learn More
    - OEM Reagent Partnerships
      
      Trusted quality for over 25 years, our global team of advanced staining experts provide specific OEM reagents in bulk quantities, individually customized products, or OEM reagent service for diagnostic and discovery applications.
  - View All
- Digital Pathology
  - Digital Pathology
    - - Slide Scanners & Solutions
      - Management & Integration Software
      - VIEW ALL
    - Digital Pathology
      
      Adopting digital pathology is complex, but it doesn’t have to be complicated. Leica Biosystems can clarify your organization’s path to digitally driven discoveries or diagnostics. Our world-leading, modular technology is supported by experience with thousands of Aperio Digital Pathology implementations worldwide.
  - Slide Scanners & Solutions
    - Scan - Aperio Digital Pathology Slide Scanners
      
      Scanning is the first step in digital pathology; put your best foot forward.  From translational research to routine diagnostics or AI development, there is an Aperio scanner for every need.
  - Management & Integration Software
    - Aperio eSlide Manager with WebViewer DX
    - Aperio ImageScope - Pathology Slide Viewing Software
    - Management & Integration Software
    - View All
    - Manage – Aperio Digital Pathology Software
      
      Effective image management and automated systems communication are essential for digital pathology success. Secure, scalable solutions with flexible deployment options enable anytime, anywhere access to your slides.
  - View All
- Research
  - Research
    - Research
      
      Our purpose is to enable researchers to accelerate their journey, transforming scientific exploration into translational outcomes. Our goal is to shape the future with novel technologies that inspire every researcher’s exploration of biology.
  - Research Microtomes
    - - HistoCore BIOCUT R - Mechanical Manual Rotary Microtome
      - HistoCore MULTICUT R - Semi-Automated Rotary Microtome
    - Research Rotary Microtomy Solutions
      
      Built on 145+ years of market-leading microtomes, Leica Biosystems offers the next generation of microtomes specially designed for research and industry.
  - Vibratomes
    - - Leica VT1000 S - Vibrating blade microtome
      - Leica VT1200 - Semi-Automatic Vibrating Blade Microtome
      - Leica VT1200 S - Fully automated vibrating blade microtome
      - View All
    - Vibratomes
      
      Vibrating microtomes (Vibratomes) by Leica Biosystems help you to accurately cut tissue under physiologial conditions without freezing or embedding.
  - Cryostats
    - Leica CM3600 XP - Whole Body Sectioning with GLP documentation
    - Learn More
    - Cryostats
      
      Cryostats for your Cancer or Neuroscience research needs.
  - BOND IHC-ISH Instruments & Solutions
    - - BOND RX - Fast Research Stainer
      - BOND RXᵐ - Compact Research Stainer
      - BOND RX-ADVANCE Advanced Research Staining Network
      - Learn More
    - BOND IHC-ISH Instruments & Solutions
      
      Every BOND system is complete, automated, and engineered for speed, reliability and accuracy with each configuration tailored to address discovery challenges.
  - Slide Scanners & Solutions
    - - Aperio GT 450 - Automated, High Capacity Digital Pathology Slide Scanner
      - Aperio CS2 — High quality digital slides from your desktop
      - Aperio VERSA - Brightfield, Fluorescence & FISH Digital Pathology Scanner
      - Learn More
    - Scan - Aperio Digital Pathology Slide Scanners
      
      Scanning is the first step in Digital Pathology; put your best foot forward. From translational research to routine diagnostics or AI development.
  - View All
Clinical Solutions
Life Sciences
- Life Sciences Solutions
  - Life Sciences Solutions
    - Learn More
    - Life Sciences Solutions
      
      Our purpose is to enable researchers to accelerate their journey, transforming scientific exploration into translational outcomes. Our goal is to shape the future with novel technologies that inspire every researcher’s exploration of biology.
  - Specimen Preparation
    - - Research Microtomes - Research Rotary Microtomy Solutions
      - Vibratomes - Vibrating Blade Microtomy Solutions
    - Specimen Preparation
      
      From staining workstations, to a full offering of consumables, we are committed to supporting accurate and trusted results for your important daily work.
  - IHC, ISH and Emerging Tests
    - - BOND RX - Fast Research Stainer
      - BOND RXᵐ - Compact Research Stainer
      - Molecular Solutions
      - VIEW ALL
    - IHC, ISH and Emerging Tests
      
      Researchers need clear results to discover new treatments. BOND research instruments provide the flexibility you need to explore new possibilities, accurate results to ensure nothing is missed, and rapid, cost-effective operation so you can perform more tests.
  - Digital Pathology
    - - Aperio ImageScope - Pathology Slide Viewing Software
      - VIEW ALL
    - Digital Pathology
      
      Our digital slide scanning products offer unprecedented image quality, speed and reliability for whole slide imaging; making Aperio ePathology scanners the optimal choice for research professionals.
  - Consumables
    - Consumables
      
      Improve quality, reduce errors, and save time with dedicated plug and play consumables. From glass slides and coverslips to wax and bulk reagents, smooth running of any laboratory depends on a consistent supply of high-quality consumables.
  - Learn More
- Educational Resources
  - Educational Resources
    - Educational Resources
      
      Leica Biosystems provides complete access to today's hottest topics in life sciences and in tissue-based translational research.
  - Articles
    - The BOND RX Stainer - Automated Multiplexing Solutions
    - H&E Image Quality & Tissue-based Research
    - Benefits Of Automation For Tissue-Based Research
    - Cryosectioning 101 for Research Q&A
    - Tips & Tricks to Multiplexing
    - VIEW ALL
    - Articles
      
      Articles by thought leaders across the fields of Histology, Anatomic Pathology and cancer research.
  - Webinars
    - Histology Hacks for Cryosectioning
    - The Power of Spatially Resolved Staining
    - Modernization of Tissue-based, Biomarker-led Clinical Research
    - VIEW ALL
    - Webinars
      
      Live and recorded scientific educational resources presented by industry thought leaders.
  - White Papers and Case Studies
    - Strategies for Spatial Multi-omics: Co-detection of protein and RNA biomarkers on a single FFPE tissue section powered by InSituPlex® Technology
    - View All
    - White Papers and Case Studies
      
      Selected in-depth reviews of current practices and evidence-based solutions for the research community.
  - Peer-Reviewed Publications
    - VIEW ALL
    - Peer-Reviewed Publications
      
      The Leica Biosystems Life Science peer-reviewed publication repository offers a method for building a bibliography of scientific publications referencing Leica Biosystems Life Sciences products.
  - Newsletters
    - VIEW ALL
    - Newsletters
      
      Research Link: Your link to Life Sciences
  - How to Guides
    - Buying a Research Microtome: Why Quality Matters in Research Microtomy
    - Leica Biosystems Research Microtome Comparison Guide
    - 4 Tips for Buying a Microtome
    - Top Considerations When Buying a Digital Pathology Scanner
    - Tips for Choosing an Embedder
    - VIEW ALL
    - How to Guides
      
      Access additional educational resources to support your applications, including content with technical knowledge and "how-to" guides.
  - Advanced Staining Image Gallery
    - View All
    - Advanced Staining Image Gallery
      
      Explore the virtual art gallery with images showing different staining techniques such as multiplex biomarker detection in tissue samples performed on the BOND RX fully automated stainer.
- Application
  - Application
    - Multiplexing
    - Integrated Translational Research Solutions
    - Learn More
    - Application
      
      Leica Biosystems research portfolio provides instruments, solutions, and support for each step of your tissue-based journey; from biomarker to digital analysis, and beyond.
  - Multiplexing
    - LEARN MORE
    - Multiplexing
      
      Modern Multiplex Solutions for the Research Lab
      
      Multiplexing addresses the need for researchers to assess multiple biomarkers (protein and/or nucleic acid markers) at specific locations within a tissue sample
  - Integrated Translational Research Solutions
    - LEARN MORE
    - Integrated Translational Research Solutions
      
      Translational research projects are as novel as the technologies that drive them. We support scientists with solutions that bring automation, flexibility, and optimization to scale up your success and move quickly and efficiently into practical application.
  - Learn More
- Innovation Partnerships
  - Innovation Partnerships
    - NanoString
    - Advanced Cell Diagnostics (ACD)
    - Learn More
    - Innovation Partnerships
      
      Our Open Innovation (OI) partnerships enable easy integration across technologies, supporting fluorescent and chromogenic protocols, and helping to answer your most pressing research questions.
  - Learn More
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Three-dimensional Characterization of Dendritic Microstructures

Three-dimensional Characterization of Dendritic Microstructures

Published: 13 August 2009

Acta Materialia, Vol. 49, (2001), pp. 897-902

This article shows how this technology can be used: a metallic microstructure is serial-sectioned and then reconstructed. From the reconstructed microstructure the surface curvatures are determined.

<media 25241 _blank download>Download pdf</media>

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