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HistoCore BIOCUT - Manual Rotary Microtome

149BIO000C1, 14051756235

With Improved Ergonomics, Manual Microtomy Never Felt so Good

Do you desire high-speed AND comfort in your manual microtomy? If so, the HistoCore BIOCUT could be the perfect solution for you. The new generation of microtomes from Leica Biosystems is built upon our 145+ year heritage of market-leading microtome design. With new options such as the personalized coarse feed wheel and 2-in-1 blade holder, it ranks among the most ergonomically-friendly microtomes on the market.

  • Quickly and efficiently select the turn direction most comfortable for you with the Personalized Coarse Feed Wheel.
  • Shorten cleaning time from minutes to seconds with the Antistatic Waste Tray.
  • Switch between high and low-profile blades even faster without changing blade holders by using the 2-in-1 Blade Holder.
Contact us to get a quote. Call +31 850 013726 to speak with a representative.

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Product Specifications


Type: Mechanical
Nominal Supply Voltage: N/A
Nominal Frequency: N/A
Maximum Power Consumption: N/A
Protection Class: N/A
Power Fuses: N/A
Pollution Degree: N/A
Overvoltage Category: N/A
Maximum Heat Emission: N/A
Operating Temperature Range: +18°C to +30°C
Temperature Range During Storage: +5°C to +50°C
Relative Humidity During Operation: 20% to Max. 80% Non-Condensing
Relative Humidity During Storage: 10% to Max. 85% Non-Condensing

Dimensions & Weight

Width (including handwheel and coarse feed wheel): 477 mm
Depth (including waste tray): 620 mm
Height (without top tray): 295 mm
Weight (without accessories): Approx. 31 kg
Type: N/A
Width: N/A
Depth: N/A
Height: N/A
Height (in inclined position): N/A
Weight (net): N/A

Microtome Performance Specs

Specimen Feed: approx. 24 mm ±2 mm
Vertical Stroke: 70 mm ±1 mm

Large Standard Clamp: 55 x 50 x 30 mm

Super Cassette Clamp: 68 x 48 x 15 mm
Motorized Sectioning Speeds: N/A
In Manual Sectioning Mode: Approx. 40 µm (can be turned off)
In Motorized Sectioning Mode: N/A
Horizontal: ± 8°
Vertical: ± 8°
Range: 1 - 60 µm
Setting Values: 1 - 10 µm (in 1 µm increments)

10 - 20 µm (in 2 µm increments)

20 - 60 µm (in 5 µm increments)
Range: 10 µm, 30 µm
Setting Values: N/A

Additional Specifications

Handwheel Balance System:  
Handwheel Lock / Brake: 2 Mechanical Locks
Safety Hand Wheel: N/A
Coarse Feed Wheel Turn Direction: User-Selectable - Clockwise or Counter-Clockwise
Type Anti-static
Waste Tray Volume 1400 ml
Rock Mode:   - manual
Single Mode:  
Continuous Mode:  
Step Mode:  
Program Mode:  
Type: 2-in 1 for high and low profile blades
North-South Movement: ± 24 mm
East-West Movement: N/A
Lateral Displacement Function: via knife holder CE clamping top
Remaining Feed Indicator Visual
Section Counter  
Section Thickness Totalizer  
Memory Position  
Special Spindle for Precise Semi-Thin Sectioning  
Expanded Slow Speed Adjustment for Precise Semi-Thin Sectioning  
Precise 3D Object Head Stop Position  

Product Features

Antistatic Waste Tray (Brush Included)

With the Antistatic Waste Tray, BIOCUT helps you keep your workplace clean, efficient, and debris-free. The tray is made from antistatic material which prevents paraffin waste from sticking to the walls. It provides unmatched efficiency by reducing your cleaning time from minutes to seconds.

Antistatic Waste Tray (Brush Included)

2-in-1 Blade Holder

With the 2-in-1 Blade Holder, you can easily switch between high and low-profile blades without changing blade holders. In addition, compared to our previous manual microtomes, the new modular design of blade holder helps you maintain individual components and efficiently service your equipment over time.


Put (Almost) Anything on Top of your Microtome!

Our new models feature 40% more surface area on top of the microtome (23.5cm W x 27.5cm L, vs. 21.7cm W x 21.2cm L on the RM22xx series) so you can store the tools you need for your job – brushes, blades, wipes, and more.

40% more Surface Area on Microtome Top Compared to older RM22xx Series

Precision-Orientation System

Always get back to a 0-position home on the microtome, regardless of how you (or another tech) have changed the instrument's orientation.

Force Balance System

Minimize the risk of injury to the operator or specimen by an unbalanced object head.

Silent Retraction

If working in a quiet environment, BIOCUT helps you concentrate and is your ideal sectioning partner with little-to-no noise during retraction.

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Type Mechanical Semi-Motorized Motorized
Precision-Orientation System      
Force Balance System      
2-in-1 Blade Holder      
Specimen Cooling Option with RM CoolClamp      
Antistatic Waste Tray      
Silent Retraction      
Personalized Coarse Feed Wheel      
Fast Homing      
Memory Position      
Electronic Brake      






Frequently Asked Questions

HistoCore Microtomes
Does the new HistoCore RM antistatic tray fit on the older RM22xx series?

No – the microtome base plates of both series have different dimensions and are not compatible with each other.

How does the new antistatic waste tray reduce contamination?

The antistatic waste tray is made from resistant antistatic material to avoid debris sticking to the walls of the tray.

Is the new 2-in-1 blade holder compatible as a whole assembly with the older RM22xx series?

Yes – only in the combination blade holder and 2-in-1 blade holder.

Can we still use the backlighting with the new blade holder base for the 2-in-1 blade holder?

No – the 2-in-1 blade holder base does not have the cut-out for the backlighting.

Which accessories of the older RM22xx Series cannot be used with the HistoCore RMs anymore?
  1. Small section waste tray
  2. Large section waste tray
  3. Top tray – HistoCore RM top tray is 40% larger than the RM22xx series tray
  4. Cooling Device – too small to be placed on instrument top. However, it’s still good to place next to the instrument
What is the advantage of the personalized coarse feed wheel?

Convenience and ease-of-user – users can select their personal preference of coarse feed wheel turn direction. This feature is preserved from the RM22xx series, allowing users to trim at the high pace.

What is the advantage of “Fast homing”?

The return speed of the object head from front to home position has been reduced from 26 seconds (older series) to 13 seconds (new series). This accelerated speed helps to shorten the sectioning process each time the object head is returned to home position.

What is the advantage of the Memory Position?

When batch trimming and using the same height of blocks, Memory Position will help to accelerate the sectioning.

  1. First insert a new block
  2. Bring the block to the blade
  3. Set the Memo position (stored)
  4. Trim
  5. Remove block for re-cooling
  6. Press “Memo” – the object head returns to the set object change position
  7. Insert a new block – check position
  8. Trim again


Configuration 1 (149BIO000C1)

  • Manual mechanical rotary microtome
  • Includes Antistatic Section Waste Tray
  • Top Tray
  • Precision orientation with quick clamping system for specimen clamps
  • Universal cassette clamp
  • Two-in-one blade holder E for high and low-profile blades with lateral displacement function (includes blade holder base)

Basic Instrument (14051756235)

  • Manual mechanical rotary microtome
  • Anti-static waste tray, top tray, without specimen orientation or additional accessories.
  • Completely customizable with a wide selection of accessories

Configuration 3 (149BIO000C3)

  • Manual mechanical rotary microtome
  • Includes Antistatic Section Waste Tray
  • Top Tray
  • Precision orientation with quick clamping system for specimen clamps
  • Universal cassette clamp
  • Knife Holder DH for high profile blades with lateral displacement function (includes knife holder base)

Configuration 4 (149BIO000C4)

  • Manual mechanical rotary microtome
  • Includes Antistatic Section Waste Tray
  • Top Tray
  • Precision orientation with quick clamping system for specimen clamps
  • Universal cassette clamp
  • Knife Holder DL for low profile blades with lateral displacement function (includes knife holder base)

HistoCore BIOCUT Parts/Accessories