Long-term Exposure To House Dust Mites Accelerates Lung Cancer Development In Mice
||J Exp Clin Cancer Res (2023) 42:26 https://doi.org/10.1186/s13046-022-02587-9
||Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA.
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The State Key Laboratory of Respiratory Disease, Guang- dong Provincial Key Laboratory of Allergy and Clinical Immunology, Center for Immunology, Inflammation and Immune-Mediated Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Networked Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Hospital General Universitario de Alicante, Alicante, Spain.
Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.
Cell IDx Inc, San Diego, CA, USA.
Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children’s Hospital of San Diego, University of California San Diego, La Jolla, CA, USA.
Tissue Technology Shared Resource, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Division of Endocrinology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA.
Medical Research Service, Veteran Affairs San Diego Healthcare System, San Diego, CA, USA.
||Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Grifn, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, José M. González Navajas, Matt Levin, Zohreh AkhavanAghdam, Helen Snyder, David Schwartz, Ailin Tao, Laela M. Boosherhri, Hal M. Hofman, Michael Rose, Monica Valeria Estrada, Nissi Varki, Scott Herdman, Maripat Corr, Nicholas J. G. Webster, Eyal Raz and Samuel Bertin
||Individuals with certain chronic inflammatory lung diseases have a higher risk of developing lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic exposure to house dust mites (HDM), a common indoor aeroallergen associated with the development of asthma, accelerates LC development through the induction of chronic lung inflammation (CLI).
||Lung cancer, Kras, Urethane, House dust mites, Chronic inflammation, NLRP3, IL-1β, CCL2, Macrophages, Tumor microenvironment