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DiaKwant™ PD-L1 TPS
PD-L1 TPS, read cell by cell. Zero click, zero annotation, zero manual counting: when you open the slide in Aperio HALO AP Software, DiaKwant™ AI has already framed the tumor, classified each tumor cell as PD-L1 positive or negative, and computed the Tumor Proportion Score (TPS) on the entire slide, for non-small cell lung and urothelial carcinomas. A heatmap shows where PD-L1 is expressed. The score comes with the cell counts behind it. You stay in control. The AI handles the count.
For Research Use Only. Not for Use in Diagnostic Procedures.
Zoom image Region detection and counting are performed automatically
DiaKwant™ AI selects the tumor and its microenvironment on the entire slide, with no region to draw. Necrosis, normal mucosa, benign lesions, in situ carcinoma and control tissue are excluded from analysis.
DiaKwant™ PD-L1 TPS heatmap on a lung or urothelial carcinoma slide with the tumor region framed automatically.
Identify the cells of interest
Tumor cells: each tumor cell is classified PD-L1 positive or negative.
Quantify TPS: the score comes with the counts behind it: positive tumor cells and negative tumor cells. The AI handles the count you would do manually on the entire slide.
DiaKwant™ PD-L1 TPS results panel: TPS with the counts of positive and negative tumor cells.
See where PD-L1 is expressed
A heatmap across the tumor, as a TPS map. Switch it on and off to see the tissue underneath.
TPS heatmap showing where PD-L1 positive tumor cells concentrate, from low (blue) to high (red).
Tissue coverage
TPS for non-small cell lung and urothelial carcinomas.
DiaKwant™ PD-L1 TPS for non-small cell lung and urothelial carcinomas.
DiaKwant PD-L1 (TPS) Pan-organ Demonstration in Aperio HALO AP Image Management System
DiaKwant PD-L1 (TPS) Pan-organ is a DiaDeep algorithm integrated within the Aperio HALO AP digital pathology platform to deliver accurate PD-L1 quantification across tumor types, including lung and urothelial carcinomas. It automatically analyzes the whole slide to calculate the Tumor Proportion Score (TPS), with no manual annotation or selection of tumor regions required from the pathologist.
After selecting a PD-L1 slide, the pathologist can review the tissue in detail. A heatmap overlay highlights the tumor regions analyzed. The heatmap can be switched on or off at any time, allowing the pathologist to compare the algorithm's output with the underlying tissue morphology.
At the end of the analysis, the pathologist obtains:
- The TPS, with the calculated score.
- The number of positive and negative tumor cells, supporting understanding of the score.
- A heatmap of PD-L1 expression across the tumor.
DiaKwant also offers automated quantification for HER2, Ki-67, ER, PR, and mitosis.
Specifications
| Algorithm | DiaKwant PD-L1 TPS |
| Antibody clones | 22C3, 28-8, SP263, SP142 |
| Supported image formats | SVS, DICOM |
| Deployment | cloud (Software as a Service) or on-premise |
| Outputs | TPS, PD-L1 positive and negative tumor cell counts, heatmap |
| Regulatory status | Research Use Only (RUO) |