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DiaKwant™ PD-L1 Pan-Organ (CPS & TPS)
You might start enjoying quantification. Yes, even PD-L1. Zero click, zero annotation, zero manual counting: when you open the slide in Aperio HALO AP Software, DiaKwant™ AI has already framed the tumor, classified each tumor cell, lymphocyte and macrophage, and computed the Combined Positive Score (CPS) and the Tumor Proportion Score (TPS) on the entire slide, across multiple solid tumor types. A heatmap shows where PD-L1 is expressed. Each score comes with the cell counts behind it. You stay in control. The AI handles the count.
For Research Use Only. Not for Use in Diagnostic Procedures.
Zoom image Region detection and counting are performed automatically
DiaKwant™ AI selects the tumor and its microenvironment on the entire slide, with no region to draw. Necrosis, normal mucosa, benign lesions, in situ carcinoma and control tissue are excluded from analysis.
DiaKwant™ PD-L1 heatmap on the entire slide: the tumor and its microenvironment are framed automatically with PD-L1 expression from low (blue) to high (red).
Identify the cells of interest
Tumor and immune cells: each cell is classified, tumor or immune, PD-L1 positive or negative. Immune cells are identified as lymphocytes or macrophages.
Quantify CPS and TPS: both scores come with the counts behind them: positive tumor cells, negative tumor cells, positive immune cells. The AI handles the count you would do manually, on the entire slide.
DiaKwant™ PD-L1 results panel: CPS, TPS and the counts of positive tumor cells, negative tumor cells and positive immune cells.
See where PD-L1 is expressed
A heatmap across the tumor and its microenvironment, as a CPS or TPS map. Switch it on and off to see the tissue underneath.
Local CPS heatmap at higher magnification (left), with the slide overview and the viewed area outlined (right).
Tissue coverage
CPS for breast, head and neck, gastrointestinal and cervical carcinomas. TPS for non-small cell lung and urothelial carcinomas.
DiaKwant™ PD-L1 in Aperio HALO AP Software for breast, cervical, gastrointestinal and head and neck carcinomas with the local CPS heatmap and the results panel.
DiaKwant PD-L1 (CPS, TPS) Pan-organ Demonstration in Aperio HALO AP Image Management System
DiaKwant PD-L1 (CPS, TPS) Pan-organ is a DiaDeep algorithm integrated within the Aperio HALO AP digital pathology platform to deliver accurate PD-L1 quantification. It automatically analyzes the whole slide to calculate the Combined Positive Score (CPS) and Tumor Proportion Score (TPS), with no manual annotation or selection of tumor regions required from the pathologist.
After selecting a PD-L1 slide, the pathologist can review the tissue in detail. A heatmap overlay highlights the tumor regions analyzed. The heatmap can be switched on or off at any time, allowing the pathologist to compare the algorithm's output with the underlying tissue morphology. At the end of the analysis, the pathologist obtains:
- The CPS and TPS scores, with the calculated score.
- The number of positive tumor cells, negative tumor cells, and positive immune cells, supporting understanding of the score.
- A heatmap of PD-L1 expression across the tumor and its microenvironment.
DiaKwant also offers automated quantification for HER2, Ki-67, ER, PR, and mitosis.
Specifications
| Algorithm |
DiaKwant PD-L1 Pan-Organ (CPS & TPS) Antibody clones: 22C3, 28-8, SP263, SP142 |
| Supported image formats | SVS, DICOM |
| Deployment | cloud (Software as a Service) or on-premise |
| Outputs | CPS and TPS, PD-L1 positive and negative tumor cell counts, PD-L1 positive immune cell counts, heatmap |
| Regulatory status | Research Use Only (RUO) |