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H&E digital slide of invasive breast carcinoma (left) with the DiaKwant™ Mitosis AI density heatmap (right) showing where mitotic figures concentrate, from low (blue) to high (red), with the 2 mm² hotspot outlined.

DiaKwant™ Mitosis Breast

The needle in the haystack, found. Zero click, zero annotation, zero manual counting: when you open the hematoxylin and eosin (H&E) slide in Aperio HALO AP Software, DiaKwant™ AI has already framed the invasive breast carcinoma, detected the mitotic figures, located the 2 mm² hotspot of highest density and computed the mitotic score, with global and hotspot counts. A density heatmap shows each figure in context, so the score stays traceable to the tissue. You stay in control. The AI handles the count.

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For Research Use Only. Not for Use in Diagnostic Procedures.

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Region detection and counting are performed automatically

DiaKwant™ AI selects the invasive tumor on the entire H&E slide, with no region to draw. In situ components are excluded from analysis.

Mitotic density heatmap on an H&E slide with the hotspot outlined.

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Feature 2_Mitosis_Leica
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Find the mitotic figures

DiaKwant™ AI detects mitotic figures on the entire invasive area and locates the 2 mm² hotspot, equivalent to 10 consecutive high-power fields at x40, where mitotic density is highest.

Close view of the hotspot: the detected mitotic figures are marked inside the 2 mm² hotspot.

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Quantify mitosis

The mitotic score is computed on the hotspot with the global and hotspot mitotic counts. The AI handles the count you would do manually.

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Features 4_Mitosis
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See where mitosis concentrate

A density heatmap across the invasive tumor. Switch it on and off to see the tissue underneath.

DiaKwant™ Mitosis in Aperio HALO AP Software: mitotic density heatmap with the results panel (mitotic score, hotspot and global mitotic counts).

DiaKwant Mitosis Demonstration in Aperio HALO AP Image Management System

DiaKwant Mitosis is a DiaDeep algorithm integrated within the Aperio HALO AP digital pathology platform to deliver accurate mitotic quantification. It automatically analyzes the whole slide to detect mitotic figures across all invasive areas and identify the 2 mm² hotspot with the highest mitotic density, with no manual annotation or selection of invasive regions required from the pathologist.

After selecting an H&E slide, the pathologist can review the tissue in detail. A heatmap overlay highlights mitotic density across the invasive tumor. The heatmap can be switched on or off at any time, allowing the pathologist to compare the algorithm's output with the underlying tissue morphology.

At the end of the analysis, the pathologist obtains:

  • The mitotic score.
  • The hotspot mitotic count on which the score is based, and the global mitotic count across the invasive tumor.
  • The global mitotic count.
  • A heatmap of mitotic density across the invasive tumor.

DiaKwant also offers automated quantification for PD-L1, HER2, Ki-67, ER, and PR.

Specifications

Algorithm DiaKwant Mitosis Breast
Supported image formats SVS, DICOM
Deployment cloud (Software as a Service) or on-premise
Outputs

Scores:

  • Mitotic score on the 2 mm² hotspot
  • Global and hotspot mitotic counts, heatmap

 
Regulatory status Research Use Only (RUO)