Skip to main content

The Power of Spatially Resolved Staining

Bradley Spencer-Dene, Subject Matter Expert, Next Gen Histology at GSK
Elena Miranda, PhD, Director, Non-Clinical Histology at GSK

CONTACT YOUR RESEARCH EXPERT

Stay up-to-date with the latest research studies in spatially resolved staining techniques.

Chromogenic Co-detection of Protein and mRNA Targets in Tissues using the BOND RX Fully Automated Research Stainer

Bradley Spencer-Dene
Subject Matter Expert, Next Gen Histology at GSK

Co-detection of more than one target in Formalin-Fixed Paraffin Embedded samples is an extremely useful application and one that is increasingly required in modern histopathology labs. In order to detect both protein and mRNA targets in the same section we have established a semi-automated workflow for sequentially detecting protein and mRNA targets chromogenically on the BOND RX research stainer combining AP/Fast Red detection (RNAscope/Basescope in situ hybridization) with HRP/Green detection (Immunohistochemistry) to establish target mRNA expression in the context of cell lineage detection.

 

Digital Histopathology Deployment in GSK Non-Clinical Histology Facility

Elena Miranda, PhD
Director, Non-Clinical Histology at GSK

Currently, the Pathology community examines relatively small numbers of digital images of H&E stained histological sections for internal consultation and peer review harmonization. In the Non-Clinical Histology team, we focus on a new digital histopathology imaging workflow that will define the standards for histopathology in drug discovery/development for the wider GSK scientific community and expectations for external collaborators. By consolidating metadata standards, governance and data entry systems, the digital histopathology imaging workflow will enable increased application of quantitative image analytic approaches like artificial intelligence to clinical and nonclinical biomarker assays.

For Research Use Only. Not for use in diagnostic procedures

If you have viewed this educational webinar or training and would like to apply for continuing education credits with your certifying organization, please download the form to assist you in adding self-reported educational credits to your transcript.

Leica Biosystems 콘텐츠는 Leica Biosystems 웹사이트 이용 약관의 적용을 받으며, 이용 약관은 다음에서 확인할 수 있습니다. 법적고지. 라이카 바이오시스템즈 웨비나, 교육 프레젠테이션 및 관련 자료는 특별 주제 관련 일반 정보를 제공하지만 의료, 규정 또는 법률 상담으로 제공되지 않으며 해석되어서는 안 됩니다. 관점과 의견은 발표자/저자의 개인 관점과 의견이며 라이카 바이오시스템즈, 그 직원 또는 대행사의 관점이나 의견을 나타내거나 반영하지 않습니다. 제3자 자원 또는 콘텐츠에 대한 액세스를 제공하는 콘텐츠에 포함된 모든 링크는 오직 편의를 위해 제공됩니다.

모든 제품 사용에 다양한 제품 및 장치의 제품 정보 가이드, 부속 문서 및 작동 설명서를 참조해야 합니다.

Copyright © 2024 Leica Biosystems division of Leica Microsystems, Inc. and its Leica Biosystems affiliates. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH.