Peer-Reviewed Publications Repository

Image	Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks. Publication Year: 2022 Country: USA PMID: PMC8340647 Publication: Frontiers in Immunology. 2021;12. doi:10.3389/fimmu.2021.713420 Institute: Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC Instrument: Aperio GT 450 Authors: Suresh M, Li B, Murreddu MG, Gudima SO, Menne S. Study Goals: To show that the the differential expression of PRRs during resolution and persistence of WHV infection emphasizes their importance in the ultimate viral control during AHB that is impaired during CHB. Keywords: Aperio GT450
Image	Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas. Publication Year: 2021 Country: USA PMID: PMC8698999 Publication: Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766 Institute: Department of Medicine, Georgetown University, Washington Instrument: Aperio GT 450 Authors: Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST. Study Goals: To demostrate  the detection of early precancerous lesions (PanINs) in genetically engineered mice. Keywords: Aperio GT450, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs
Image	Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A. Publication Year: 2021 Country: USA PMID: PMC8774279 Publication: Toxicology Research and Application. 2021;5:239784732110471. doi:10.1177/23978473211047164 Institute: Mechanistic Toxicology Branch, Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), 111 TW Alexander Drive, Research Triangle Park, NC 27709 Instrument: Aperio AT2 Authors: Castro L, Liu J, Yu L, et al. Study Goals: To show that RTKs are dysregulated following early life TBBPA exposures and their sustained activation may contribute to TBBPA-induced uterine tumors observed in rats later in life. Keywords: Aperio AT2
Image	A single-cell-type transcriptomics map of human tissues. Publication Year: 2021 Country: Sweden PMID: PMC8318366 Publication: Nature Genetics. 2021;53(9):1275-1275. doi:10.1038/s41588-021-00938-4 Institute: Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology, Stockholm Instrument: Aperio AT2 Authors: Alam O. Study Goals: To create a a high-resolution single–cell type map of human tissues. Keywords: Aperio AT2
Image	Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model. Publication Year: 2021 Country: USA PMID: PMC8848646 Publication: BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3 Institute: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Instrument: Aperio AT2 Authors: Delahoussaye AM, Abi Jaoude J, Green M, et al. Study Goals: To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer. Keywords: Aperio AT2
Image	Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma. Publication Year: 2021 Country: USA PMID: PMC8345222 Publication: Cancers. 2021;13(15):3743. doi:10.3390/cancers13153743 Institute: Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 Instrument: Aperio AT2 Authors: Chakiryan NH, Kimmel GJ, Kim Y, et al. Study Goals: To demonstarte that close proximity to Cancer-associated fibroblasts (CAFs) potentiates tumor cell proliferation, worsening survival and conferring resistance to targeted therapies. Keywords: Aperio AT2
Image	Deep Learning of Histopathology Images at the Single Cell Level. Publication Year: 2021 Country: USA PMID: PMC8461055 Publication: Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641 Institute: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL Instrument: Aperio AT2 Authors: Lee K, Lockhart JH, Xie M, et al. Study Goals: To systematically  review the various machine learning methods with a focus on cell-level analysis. Keywords: Aperio AT2
Image	Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging. Publication Year: 2021 Country: UK PMID: PMC8073208 Publication: Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 Institute: Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB Instrument: Aperio CS2 Authors: Flint LE, Hamm G, Ready JD, et al. Study Goals: To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. Keywords: Aperio CS2
Image	Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats. Publication Year: 2021 Country: Taiwan PMID: PMC8236591 Publication: Frontiers in Neural Circuits. 2021;15. doi:10.3389/fncir.2021.693073 Institute: Department of Life Science, National Taiwan University, Taipei Instrument: Aperio CS2 Authors: Kuo C-W, Chang M-Y, Liu H-H, et al. Study Goals: To demonstrate a novel CES scheme with a theta-burst stimulation (TBS) protocol to identify the therapeutic potential of cortical electrical stimulation (CES) in a weight drop-induced rat model of traumatic brain injury (TBI). Keywords: Aperio CS2
Image	Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors. Publication Year: 2021 Country: Taiwan PMID: PMC7864566 Publication: Science Advances. 2021;7(6). doi:10.1126/sciadv.abd0772 Institute: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan Instrument: Aperio CS2 Authors: Chen K-T, Chai W-Y, Lin Y-J, et al. Study Goals: To provide evidence of focused ultrasound (FUS)-induced immune modulation as an additional therapeutic benefit by converting the immunosuppressive  tumor microenvironment  (TME) into an immunostimulatory TME via a higher but safe FUS dosage. Keywords: Aperio CS2
Image	Cardioprotective Effects of Palmitoleic Acid (C16:1n7) in a Mouse Model of Catecholamine-Induced Cardiac Damage Are Mediated by PPAR Activation. Publication Year: 2021 Country: Germany PMID: PMC8657733 Publication: International Journal of Molecular Sciences. 2021;22(23):12695. doi:10.3390/ijms222312695 Institute: Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10115 Berlin Instrument: Aperio CS2 Authors: Betz IR, Qaiyumi SJ, Goeritzer M, et al. Study Goals: C16:1n7 might have protective effects on cardiac fibrosis and inflammation.  Keywords: Aperio CS2
Image	Deep Learning of Histopathology Images at the Single Cell Level. Publication Year: 2021 Country: USA PMID: PMC8461055 Publication: Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641 Institute: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL Instrument: Aperio Versa Authors: Lee K, Lockhart JH, Xie M, et al. Study Goals: To systematically  review the various machine learning methods with a focus on cell-level analysis. Keywords: Aperio Versa, histopathology image analysis, deep learning, image data labeling, cell type classification, tumor immune microenvironment, tumor heterogeneity
Image	NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice. Publication Year: 2021 Country: China PMID: PMC8535822 Publication: Science Advances. 2021;7(43). doi:10.1126/sciadv.abi9471 Institute: State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital of Xiamen University, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, Instrument: Aperio Versa Authors: Zhang P, Liu Y, Hu L, et al. Study Goals: To study NLRC4-mediated cell death and tissue damage Keywords: Aperio Versa
Image	In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET. Publication Year: 2021 Country: USA PMID: PMC8554823 Publication: ACS Central Science. 2021;7(10):1638-1649. doi:10.1021/acscentsci.1c00529 Institute: Department of Radiology and Biomedical Imaging Instrument: Aperio Versa Authors: Zhao N, Bardine C, Lourenço AL, et al. Study Goals: To evaluate whether granzyme biochemistry can be assessed in vivo using an imaging modality that can be scaled vertically into human subjects Keywords: Aperio Versa
Image	Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models. Publication Year: 2021 Country: USA PMID: PMC8561005 Publication: iScience. 2021;24(11):103245. doi:10.1016/j.isci.2021.103245 Institute: Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco Instrument: Aperio Versa Authors: Das M, Mao W, Shao E, et al. Study Goals: To understand whether Increased expression of TREM2 seems to support microglial activities that counteract AD related network dysfunction Keywords: Aperio Versa
Image	Computational Model-Based Estimation of Mouse Eyeball Structure From Two-Dimensional Flatmount Microscopy Images. Publication Year: 2021 Country: USA PMID: PMC8088229 Publication: Translational Vision Science & Technology. 2021;10(4):25. doi:10.1167/tvst.10.4.25 Institute: Department of Mathematics and Statistics, Georgia State University, Atlanta, GA Instrument: Imagescope/Aperio Software Authors: Li H, Yu H, Kim Y-K, et al. Study Goals: To investigate a  a new method for estimating the three-dimensional (3D) eyeball sphere from two-dimensional tissue flatmount microscopy images Keywords: Aperio CS2
Image	Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging. Publication Year: 2021 Country: UK PMID: PMC8073208 Publication: Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 Institute: Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB Instrument: Imagescope/Aperio Software Authors: Flint LE, Hamm G, Ready JD, et al. Study Goals: To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. Keywords: Aperio CS2
Image	Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas. Publication Year: 2021 Country: USA PMID: PMC8698999 Publication: Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766 Institute: Department of Medicine, Georgetown University, Washington Instrument: Imagescope/Aperio Software Authors: Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST. Study Goals: To demostrate  the detection of early precancerous lesions (PanINs) in genetically engineered mice. Keywords: Aperio AT2, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs
	Analysis of immunobiologic markers in primary and recurrent glioblastoma. Publication Year: 2018 Country: USA, Florida PMID: 29302887 Publication: Journal of Neuro-Oncology. 2018;137(2):249-257. doi:10.1007/s11060-017-2732-1 Institute: University of Florida Instrument: Imagescope/Aperio Software Authors: Rahman M, Kresak J, Yang C, et al. Study Goals: To evaluate the expression of immunologic markers of potential clinical significance in primary versus recurrent GBM and assess the relationship between these markers and molecular characteristics of GBM. Keywords: immune infiltrates, tumor infiltrating lymphocytes, immunobiologic markers, high grade glioma, glioblastoma
	Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model. Publication Year: 2021 Country: USA PMID: PMC8848646 Publication: BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3 Institute: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Instrument: BOND RX Authors: Delahoussaye AM, Abi Jaoude J, Green M, et al. Study Goals: To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer. Keywords: BOND RX, Gemcitabine; KPC mice; Nab-paclitaxel; Pancreatic cancer; SBRT; mFOLFIRINOX
	Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation. Publication Year: 2021 Country: New Zealand PMID: PMC8017302 Publication: Frontiers in Surgery. 2021;8. doi:10.3389/fsurg.2021.621089 Institute: Gillies McIndoe Research Institute, Wellington Instrument: BOND RX Authors: Luke Krishnan CS, Brasch HD, Patel J, et al. Study Goals: Investigated the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial AVM Keywords: BOND RX stainer

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