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Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.
Publication Year: |
2022 |
Country: |
USA |
PMID: |
PMC8340647 |
Publication: |
Frontiers in Immunology. 2021;12. doi:10.3389/fimmu.2021.713420 |
Institute: |
Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC |
Instrument:
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Aperio GT 450 |
Authors: |
Suresh M, Li B, Murreddu MG, Gudima SO, Menne S. |
Study Goals: |
To show that the the differential expression of PRRs during resolution and persistence of WHV infection emphasizes their importance in the ultimate viral control during AHB that is impaired during CHB. |
Keywords: |
Aperio GT450 |
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Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8698999 |
Publication: |
Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766 |
Institute: |
Department of Medicine, Georgetown University, Washington |
Instrument:
|
Aperio GT 450 |
Authors: |
Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST. |
Study Goals: |
To demostrate the detection of early precancerous lesions (PanINs) in genetically engineered mice. |
Keywords: |
Aperio GT450, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs |
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Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8774279 |
Publication: |
Toxicology Research and Application. 2021;5:239784732110471. doi:10.1177/23978473211047164 |
Institute: |
Mechanistic Toxicology Branch, Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), 111 TW Alexander Drive, Research Triangle Park, NC 27709 |
Instrument:
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Aperio AT2 |
Authors: |
Castro L, Liu J, Yu L, et al. |
Study Goals: |
To show that RTKs are dysregulated following early life TBBPA exposures and their sustained activation may contribute to TBBPA-induced uterine tumors observed in rats later in life. |
Keywords: |
Aperio AT2 |
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A single-cell-type transcriptomics map of human tissues.
Publication Year: |
2021 |
Country: |
Sweden |
PMID: |
PMC8318366 |
Publication: |
Nature Genetics. 2021;53(9):1275-1275. doi:10.1038/s41588-021-00938-4 |
Institute: |
Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology, Stockholm |
Instrument:
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Aperio AT2 |
Authors: |
Alam O. |
Study Goals: |
To create a a high-resolution single–cell type map of human tissues. |
Keywords: |
Aperio AT2 |
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Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8848646 |
Publication: |
BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3 |
Institute: |
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
Instrument:
|
Aperio AT2 |
Authors: |
Delahoussaye AM, Abi Jaoude J, Green M, et al. |
Study Goals: |
To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer. |
Keywords: |
Aperio AT2 |
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Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8345222 |
Publication: |
Cancers. 2021;13(15):3743. doi:10.3390/cancers13153743 |
Institute: |
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 |
Instrument:
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Aperio AT2 |
Authors: |
Chakiryan NH, Kimmel GJ, Kim Y, et al. |
Study Goals: |
To demonstarte that close proximity to Cancer-associated fibroblasts (CAFs) potentiates tumor cell proliferation, worsening survival and conferring resistance to targeted therapies. |
Keywords: |
Aperio AT2 |
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Deep Learning of Histopathology Images at the Single Cell Level.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8461055 |
Publication: |
Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641 |
Institute: |
Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL |
Instrument:
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Aperio AT2 |
Authors: |
Lee K, Lockhart JH, Xie M, et al. |
Study Goals: |
To systematically review the various machine learning methods with a focus on cell-level analysis. |
Keywords: |
Aperio AT2 |
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Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging.
Publication Year: |
2021 |
Country: |
UK |
PMID: |
PMC8073208 |
Publication: |
Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 |
Institute: |
Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB |
Instrument:
|
Aperio CS2 |
Authors: |
Flint LE, Hamm G, Ready JD, et al. |
Study Goals: |
To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. |
Keywords: |
Aperio CS2 |
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Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats.
Publication Year: |
2021 |
Country: |
Taiwan |
PMID: |
PMC8236591 |
Publication: |
Frontiers in Neural Circuits. 2021;15. doi:10.3389/fncir.2021.693073 |
Institute: |
Department of Life Science, National Taiwan University, Taipei |
Instrument:
|
Aperio CS2 |
Authors: |
Kuo C-W, Chang M-Y, Liu H-H, et al. |
Study Goals: |
To demonstrate a novel CES scheme with a theta-burst stimulation (TBS) protocol to identify the therapeutic potential of cortical electrical stimulation (CES) in a weight drop-induced rat model of traumatic brain injury (TBI). |
Keywords: |
Aperio CS2 |
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Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors.
Publication Year: |
2021 |
Country: |
Taiwan |
PMID: |
PMC7864566 |
Publication: |
Science Advances. 2021;7(6). doi:10.1126/sciadv.abd0772 |
Institute: |
Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan |
Instrument:
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Aperio CS2 |
Authors: |
Chen K-T, Chai W-Y, Lin Y-J, et al. |
Study Goals: |
To provide evidence of focused ultrasound (FUS)-induced immune modulation as an additional therapeutic benefit by converting the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME via a higher but safe FUS dosage. |
Keywords: |
Aperio CS2 |
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Cardioprotective Effects of Palmitoleic Acid (C16:1n7) in a Mouse Model of Catecholamine-Induced Cardiac Damage Are Mediated by PPAR Activation.
Publication Year: |
2021 |
Country: |
Germany |
PMID: |
PMC8657733 |
Publication: |
International Journal of Molecular Sciences. 2021;22(23):12695. doi:10.3390/ijms222312695 |
Institute: |
Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10115 Berlin |
Instrument:
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Aperio CS2 |
Authors: |
Betz IR, Qaiyumi SJ, Goeritzer M, et al. |
Study Goals: |
C16:1n7 might have protective effects on cardiac fibrosis and inflammation. |
Keywords: |
Aperio CS2 |
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Deep Learning of Histopathology Images at the Single Cell Level.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8461055 |
Publication: |
Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641 |
Institute: |
Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL |
Instrument:
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Aperio Versa |
Authors: |
Lee K, Lockhart JH, Xie M, et al. |
Study Goals: |
To systematically review the various machine learning methods with a focus on cell-level analysis. |
Keywords: |
Aperio Versa, histopathology image analysis, deep learning, image data labeling, cell type classification, tumor immune microenvironment, tumor heterogeneity |
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NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice.
Publication Year: |
2021 |
Country: |
China |
PMID: |
PMC8535822 |
Publication: |
Science Advances. 2021;7(43). doi:10.1126/sciadv.abi9471 |
Institute: |
State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital of Xiamen University, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, |
Instrument:
|
Aperio Versa |
Authors: |
Zhang P, Liu Y, Hu L, et al. |
Study Goals: |
To study NLRC4-mediated cell death and tissue damage |
Keywords: |
Aperio Versa |
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In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8554823 |
Publication: |
ACS Central Science. 2021;7(10):1638-1649. doi:10.1021/acscentsci.1c00529 |
Institute: |
Department of Radiology and Biomedical Imaging |
Instrument:
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Aperio Versa |
Authors: |
Zhao N, Bardine C, Lourenço AL, et al. |
Study Goals: |
To evaluate whether granzyme biochemistry can be assessed in vivo using an imaging modality that can be scaled vertically into human subjects |
Keywords: |
Aperio Versa |
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Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8561005 |
Publication: |
iScience. 2021;24(11):103245. doi:10.1016/j.isci.2021.103245 |
Institute: |
Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco |
Instrument:
|
Aperio Versa |
Authors: |
Das M, Mao W, Shao E, et al. |
Study Goals: |
To understand whether Increased expression of TREM2 seems to support microglial activities that counteract AD related network dysfunction |
Keywords: |
Aperio Versa |
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Computational Model-Based Estimation of Mouse Eyeball Structure From Two-Dimensional Flatmount Microscopy Images.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8088229 |
Publication: |
Translational Vision Science & Technology. 2021;10(4):25. doi:10.1167/tvst.10.4.25 |
Institute: |
Department of Mathematics and Statistics, Georgia State University, Atlanta, GA |
Instrument:
|
Imagescope/Aperio Software |
Authors: |
Li H, Yu H, Kim Y-K, et al. |
Study Goals: |
To investigate a a new method for estimating the three-dimensional (3D) eyeball sphere from two-dimensional tissue flatmount microscopy images |
Keywords: |
Aperio CS2 |
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Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging.
Publication Year: |
2021 |
Country: |
UK |
PMID: |
PMC8073208 |
Publication: |
Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 |
Institute: |
Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB |
Instrument:
|
Imagescope/Aperio Software |
Authors: |
Flint LE, Hamm G, Ready JD, et al. |
Study Goals: |
To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. |
Keywords: |
Aperio CS2 |
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Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8698999 |
Publication: |
Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766 |
Institute: |
Department of Medicine, Georgetown University, Washington |
Instrument:
|
Imagescope/Aperio Software |
Authors: |
Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST. |
Study Goals: |
To demostrate the detection of early precancerous lesions (PanINs) in genetically engineered
mice. |
Keywords: |
Aperio AT2, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs |
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Analysis of immunobiologic markers in primary and recurrent glioblastoma.
Publication Year: |
2018 |
Country: |
USA, Florida |
PMID: |
29302887 |
Publication: |
Journal of Neuro-Oncology. 2018;137(2):249-257. doi:10.1007/s11060-017-2732-1 |
Institute: |
University of Florida |
Instrument:
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Imagescope/Aperio Software |
Authors: |
Rahman M, Kresak J, Yang C, et al. |
Study Goals: |
To evaluate the expression of immunologic markers of potential clinical significance in primary versus recurrent GBM and assess the relationship between these markers and molecular characteristics of GBM. |
Keywords: |
immune infiltrates, tumor infiltrating lymphocytes, immunobiologic markers, high grade glioma, glioblastoma |
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Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.
Publication Year: |
2021 |
Country: |
USA |
PMID: |
PMC8848646 |
Publication: |
BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3 |
Institute: |
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
Instrument:
|
BOND RX |
Authors: |
Delahoussaye AM, Abi Jaoude J, Green M, et al. |
Study Goals: |
To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer. |
Keywords: |
BOND RX, Gemcitabine; KPC mice; Nab-paclitaxel; Pancreatic cancer; SBRT; mFOLFIRINOX |
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Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.
Publication Year: |
2021 |
Country: |
New Zealand |
PMID: |
PMC8017302 |
Publication: |
Frontiers in Surgery. 2021;8. doi:10.3389/fsurg.2021.621089 |
Institute: |
Gillies McIndoe Research Institute, Wellington |
Instrument:
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BOND RX |
Authors: |
Luke Krishnan CS, Brasch HD, Patel J, et al. |
Study Goals: |
Investigated the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial AVM |
Keywords: |
BOND RX stainer |
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