Muc Glycoprotein Antibodies Novocastra
Mucins are heavily glycosylated proteins which constitute the major components of mucus covering the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have reported that these mucins are differentially expressed in epithelia with cell-type specificity. The normal gastric mucosa shows cell-type specific expression of Muc-1, Muc-5AC and Muc-6 glycoproteins. Muc-1 and Muc-5AC are found in superficial epithelium and Muc-6 glycoprotein in the deep glands. Muc-1 and Muc-5AC glycoproteins are reported to be expressed in many epithelia but Muc-6 glycoprotein is mainly expressed in gastric mucosa. In addition, Muc-2 glycoprotein is not expressed in normal gastric mucosa. In gastric cancer, alterations in mucin polypeptide expression have been reported, including the loss of expression of Muc-5AC glycoprotein, increased mucin heterogeneity, glycosylation changes and the expression of simple mucin-type carbohydrates.