Muc Glycoprotein Antibodies Primary Antibodies

Muc Glycoprotein Antibodies Novocastra

Normal human stomach: immunohistochemical staining for Muc-6 glycoprotein using NCL-MUC-6. Note cytoplasmic staining of mucus secreting cells of the deep glands. Paraffin section.
Normal human stomach: immunohistochemical staining for Muc-6 glycoprotein using NCL-MUC-6. Note cytoplasmic staining of mucus secreting cells of the deep glands. Paraffin section.

Antigen Background

Mucins are heavily glycosylated proteins which constitute the major components of mucus covering the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have reported that these mucins are differentially expressed in epithelia with cell-type specificity. The normal gastric mucosa shows cell-type specific expression of Muc-1, Muc-5AC and Muc-6 glycoproteins. Muc-1 and Muc-5AC are found in superficial epithelium and Muc-6 glycoprotein in the deep glands. Muc-1 and Muc-5AC glycoproteins are reported to be expressed in many epithelia but Muc-6 glycoprotein is mainly expressed in gastric mucosa. In addition, Muc-2 glycoprotein is not expressed in normal gastric mucosa. In gastric cancer, alterations in mucin polypeptide expression have been reported, including the loss of expression of Muc-5AC glycoprotein, increased mucin heterogeneity, glycosylation changes and the expression of simple mucin-type carbohydrates.