*/ This Item has been discontinued Replaced by Leica CM1860

In-surgery cancer diagnostics relies on reproducible section quality within minutes. The Leica CM1860 UV  cryostat gives you the confidence to consistently produce quality sections that help provide an accurate diagnosis. The Leica Premium blade holder helps to prevent cutting injures by minimizing direct contact with the blade.

In-surgery cancer diagnostics relies on reproducible section quality within minutes. The Leica CM1860 cryostat gives you the confidence to consistently produce quality sections. The Leica Premium blade holder helps to prevent cutting injuries by minimizing direct contact with the blade.

H&E is an important tool for disease research and drug development and is being increasingly combined with digital pathology technology. Image quality is important for slide digitization to ensure that interpretation is accurate. Take a look at some images here, produced by our digital pathology scanners.

In the webinar Cryosectioning 101 for Research, John Stock provided a comprehensive guide on achieving better cryosectioning outcomes. John went on to answer customer questions at the end of the session, that have been compiled for your viewing here.

Antigen BackgroundEstrogen receptor (ER) content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. The introduction of highly specific monoclonal antibodies to ER has allowed the determination of receptor status of breast tumors to be carried out in routine histopathology laboratories.Product Specific InformationClone 6F11 is raised to the full length alpha form of the estrogen rec...

Antigen BackgroundProgrammed death-ligand 1 (PD-L1), CD274 or B7 Homolog 1(B7-H1) is a protein encoded by the CD274 gene. When bound to its ligands, PD-1 and B7.1, it plays an immunosuppressive role by inhibiting T-cell activity. Overexpression of PD-L1 by cancer cells may enable them to evade the host immune response, conferring a growth advantage to such tumours. PD-L1 expression levels detected by immunohistochemistry can therefore be of progn...

Antigen BackgroundClone 22C9 reacts with the gamma subunit of the enolase isoenzyme. DisclaimerNeuron Specific Enolase is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Antigen BackgroundMyoD1 recognizes an epitope near the C-terminus of the MyoD1 protein (amino acids 180 to 189). DisclaimerMyoD1 (Rhabdomyosarcoma Marker) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.