9 result(s) for 'Ultivue'
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This white paper highlights the value of an integrated ISP-in situ hybridization (ISH) workflow for co-detection of protein and RNA targets on a single FFPE tissue section.
Phenotyping Tumor Microenvironment Using DNA Barcoded Multiplex Technology Chifei Sun GSK IVIVTBIBCellular Biomarkers Collegeville, PA
I have no conflict of interests with Leica Biosystems, Ultivue and Indica Labs. – All the materials used in this presentation are for educational purpose only. – The human biological samples were sourced ethically, and their research use was in accord with the terms of the informed consents under an IRB/EC approved protocol. Statement 9/25/2020 2
Understand the complexity of tumor microenvironment and its importance in drug development – Introduce the Ultivue DNA barcoding and exchange technology for multiplex immunofluorescence – Highlight the processes of image fusion, spatial analysis and colocalization of markers on individual cells Learning...
Gourab Chatterjee joined Ultivue over 5 years ago and played integral roles towards developing the foundational InSituPlex technology and building the FixVUE. FlexVUE and UVUE product portfolios. He is currently leading the research and development efforts at Ultivue towards expanding the applications of ISP technology towards fast and accurate multiplexed biomarker detection across diverse areas of interest in spatial phenomics.
Gourab graduated with B. Tech. and M. Tech. degrees in Biotechnology and Biochemical Engineering from the Indian Institute of Technology Kharagpur, India. Following that, he pursued his Ph.D. in Bioengineering from University of Washington Seattle with Georg Seelig, where he developed novel nucleic acid-based nanoscale computational devices for in-vitr...
Kirsty Maclean has 20 years of leadership experience addressing academic, biotech, clinical research organizations (CRO) and pharmaceutical industries through clinical/technical communication, sales support, and strategic market intelligence. Previously Kirsty held leadership roles in commercial development and scientific communications at CodexDNA, Definiens (now part of AstraZeneca), Nanostring Technologies and ThermoFisher Scientific. Prior to industry, Kirsty spent 8 years as a post-doctoral researcher and staff scientist at St. Jude Children’s Research Hospital, and to date has over 35 peer reviewed publications and book chapters. She holds a PhD in Hematology and a BS (Hons) in Biochemistry.
Introduction to immuno oncology
1. Introduction to Immuno-Oncology Michael Bates, MD Oncology Strategy, Medical and Scientific Affairs Cepheid Sunnyvale, CA Cepheid and Leica Biosystems are Danaher Companies
2. Overview • History of Immuno-Oncology • Types of Immunotherapy • Immunomodulatory agents • Personalized Cancer Vaccines • CAR-T cell therapy • Immune Checkpoint Inhibitors • Focus: Immune Checkpoint Biomarkers
3. Evolution of Cancer Immunotherapy • William Coley – 1890s surgeon • Coley’s toxin… • BCG, IFN-alpha, IL-2 • IL-2 applications in melanoma and RCC proved that advanced metastatic cancers can be controlled in some patients by stimulating T cells with cytokines • Critical development • CTLA-4 shown to be inhibitory for T cell responses by James Allison and Jeff Blu...
It’s Time for TIME Alexander “Sandy” Borowsky Professor of Pathology and Laboratory Medicine Center for Immunology and Infectious Diseases
Disclosures Bristol-Meyers Squibb/Celgene: Funded through Investigator Sponsored Research (ISR) program. Discovery proposal. Leica/Aperio: Funded to run the “Genesis” study for primary diagnosis from whole slide images. Honorarium for this presentation. Histolix: Slide-free histology (Levenson and Fereidouni). Pfizer: Pfizer Protocol A9001502, Treatment Resistance Following Therapies (TRANSLATE) site PI. Agenda: In contracting to join the “FLEX” registry. None of these has actually paid me, only funding for the research projects.
Objectives • Introduction into the complexity of the TIME and the development of new cancer treatments though di...