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Antigen Background
Postmeiotic segregation increased 2 (PMS2), also known as PMS1 protein homologue 2, is a DNA mismatch repair (MMR) protein. The PMS2 gene family members are found in clusters on chromosome 7. PMS2 is a 96 kDa mismatch repair protein closely related to MLH1, MLH3 and PMS1, which are homologs of the bacterial mutL gene. The PMS2 protein forms a heterodimer with the MLH1 protein which is then activated in the presence of ATP; this...