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Peer-Reviewed Publications Repository

The Leica Biosystems Life Science peer-reviewed publication repository offers a method for building a bibliography of scientific publications referencing Leica Biosystems Life Sciences products.
For Research Use Only. Not for use in diagnostic procedures.

Unravelling New Roles Of A Tomato SIN3 Homolog In Leaf Polarity Mediated By Auxin Signaling And Leaf Growth-Related Transcription Factors

Publication Year: 2022
Country: China
PMID: N/A
Publication: Scientia Horticulturae. 2022;300:111055. doi:10.1016/j.scienta.2022.111055
Institute: Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang A&F University, Hangzhou 311300, Zhejiang

Instrument:

Leica HistoCore NANOCUT R
Authors: Liu Y, Fei S, Chen Y, et al.
Study Goals: To explore a new role of SIN3 in leaf polarity and provide a possible action mechanism of SlSIN3a in leaf development.
Keywords: Tomato, SIN3, Leaf development, Adaxial–abaxial polarity, Leica HistoCore NANOCUT R
   

A Previously Unknown Feeding Mode In Millipedes And The Convergence Of Fluid Feeding Across Arthropods

Publication Year: 2022
Country: Germany
PMID: PMC8849289
Publication: Science Advances. 2022;8(7). doi:10.1126/sciadv.abm0577
Institute: Zoological Research Museum Alexander Koenig, Leibniz Institute for the Analysis of Biodiversity Change, Section Myriapoda, Adenauerallee 160, 53113 Bonn

Instrument:

Leica HistoCore NANOCUT R
Authors: Moritz L, Borisova E, Hammel JU, Blanke A, Wesener T.
Study Goals: To trace the evolution of suctorial feeding in arthropods.
Keywords: Arthropods, Diplopoda, Pumping chamber, Fluid feeding, Leica HistoCore NANOCUT R
   

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

Publication Year: 2022
Country: USA
PMID: PMC8955233
Publication: Viruses. 2022;14(3):535. doi:10.3390/v14030535
Institute: Louisiana Animal Disease Diagnostic Laboratory (LADDL), Louisiana State University, Baton Rouge, LA 61329

Instrument:

BOND RXm
Authors: Carossino M, Kenney D, O’Connell AK, et al.
Study Goals: To analyse neuroinvasion and neurodissemination in humans call into question the translational relevance of this model.
Keywords: BOND RXm, translational animal model; comparative pathology; immunohistochemistry; in situ hybridization; viral pathogenesis; transmission electron microscopy; in vivo imaging
   
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Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.

Publication Year: 2022
Country: USA
PMID: PMC8340647
Publication: Frontiers in Immunology. 2021;12. doi:10.3389/fimmu.2021.713420
Institute: Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC

Instrument:

Aperio GT 450
Authors: Suresh M, Li B, Murreddu MG, Gudima SO, Menne S.
Study Goals: To show that the the differential expression of PRRs during resolution and persistence of WHV infection emphasizes their importance in the ultimate viral control during AHB that is impaired during CHB.
Keywords: Aperio GT450
   

An Injectable Mesoporous Silica-Based Analgesic Delivery System Prolongs The Duration Of Sciatic Nerve Block In Mice With Minimal Toxicity

Publication Year: 2021
Country: China
PMID: 34520884
Publication: Acta Biomaterialia. 2021;135:638-649. doi:10.1016/j.actbio.2021.09.008
Institute: Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233

Instrument:

Leica HistoCore NANOCUT R
Authors: Wang H, Zhang Y, Xu X, Wang A.
Study Goals: To demonstrate the potential of the mesoporous silica-based analgesic nanocomposites in effectively controlling postoperative pain
Keywords: Postoperative pain management, Long-lasting anesthetics, Mesoporous silica Injectable nanocomposite, Leica HistoCore Nanocut R
   

A Tarsal Spinning Organ In Glomeridesmid Millipedes (Diplopoda: Pentazonia: Glomeridesmida)

Publication Year: 2021
Country: Germany
PMID: N/A
Publication: Arthropod Systematics & Phylogeny. 2021;79:555-567. doi:10.3897/asp.79.e70002
Institute: Zoological Research Museum Alexander Koenig, Leibniz Institute for Animal Biodiversity, Adenauerallee 160, 53113 Bonn

Instrument:

Leica HistoCore NANOCUT R
Authors: Moritz L, Wesener T.
Study Goals: To describe thread-producing glands from the species-poor Glomeridesmida
Keywords: Exocrine gland, Glomeridesmus, leg, Limacomorpha, scanning electron microscopy, silk, spinnerets, Termitodesmus, Leica HistoCore NANOCUT R
   

CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue

Publication Year: 2021
Country: USA
PMID: N/A
Publication: Scientific Reports. 2021;11(1). doi:10.1038/s41598-021-96979-0
Institute: Fred Hutchinson Cancer Research Center, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute

Instrument:

BOND RX
Authors: Eichholz K, Li AZ, Diem K, Jensen MC, Zhu J, Corey L. A
Study Goals: A CAR RNA FISH histo-cytometry platform combined with a random reaction seed image analysis algorithm to quantitate spatial distribution and in vivo functional activity of a CAR T cell population at a single cell resolution for preclinical models.
Keywords: BOND RX, Chimeric antigen receptor, (CAR) T, CAR RNA FISH, histo-cytometry
   

A non-clinical comparative study of IL-23 antibodies in psoriasis

Publication Year: 2021
Country: USA
PMID: 34460338
Publication: mAbs. 2021;13(1). doi:10.1080/19420862.2021.1964420
Institute: Abbvie Bioresearch Center, Worcester

Instrument:

BOND RX
Authors: Zhou L, Wang Y, Wan Q, et al.
Study Goals: To investigate if four clinically approved antibodies targeting IL-23 differ in affinity and binding epitope
Keywords: BOND RX, IL-23, IL-12, psoriasis, autoimmune disease, risankizumab, guselkumab, tildrakizumab, ustekinumab
   

Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model

Publication Year: 2021
Country: France
PMID: PMC8376007
Publication: PLOS Pathogens. 2021;17(8):e1009427. doi:10.1371/journal.ppat.1009427
Institute: Ecole nationale vétérinaire de Toulouse, ENVT, INRAE, UMR 1225, IHAP, Université de Toulouse, Toulouse

Instrument:

BOND RXm
Authors: Bessière P, Wasniewski M, Picard-Meyer E, et al.
Study Goals: To investigate whether early type I IFN treatment is beneficial, while late interventions are ineffective, although not associated with signs of enhanced disease.
Keywords: BOND RXm
   

Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

Publication Year: 2021
Country: USA
PMID: PMC7930198
Publication: Nature Communications. 2021;12(1). doi:10.1038/s41467-021-21615-4
Institute: Fred Hutchinson Cancer Research Center, Seattle, WA

Instrument:

BOND RXm
Authors: Brady L, Kriner M, Coleman I, et al.
Study Goals: To demonstrate the utility of digital spatial profiling for accurately classifying tumor phenotype, assessing tumor heterogeneity, and identifying aspects of tumor biology involving the immunological composition of metastases.
Keywords: BOND RXm, metastatic prostate cancer, tumor heterogeneity, tumor phenotype, digital spatial profiling (DSP), multiplex
   

Immunohistochemical Characterization of a Duodenal Adenocarcinoma with Pulmonary, Hepatic and Parapatellar Metastases in a Common Marmoset (Callithrix jacchus)

Publication Year: 2021
Country: USA
PMID: N/A
Publication: Journal of Comparative Pathology
Institute: Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, Maryland

Instrument:

BOND RXm
Authors: Peterson C, Plunkard J, Johanson A, Izzi J, Gabrielson K.
Study Goals: To investigate proximal duodenal adenocarcinoma with extensive metastatic disease in a common marmoset
Keywords: BOND RXm, common marmoset; duodenal mucinous adenocarcinoma; metastases; pancytokeratin
   

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.

Publication Year: 2021
Country: UK
PMID: PMC8187652
Publication: Nature Communications. 2021;12(1). doi:10.1038/s41467-021-23717-5
Institute: Cancer Research UK Beatson Institute, Glasgow

Instrument:

BOND RX
Authors: Leach JDG, Vlahov N, Tsantoulis P, et al.
Study Goals: To study a mouse model of right-sided colon cancer driven by oncogenic BRAF and loss of epithelial TGFβ-receptor signalling
Keywords: BOND RX, colorectal cancer, oncogenic BRAF, epithelial TGFβ-receptor signaling, RNAscope, Multiplex
   
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Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas.

Publication Year: 2021
Country: USA
PMID: PMC8698999
Publication: Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766
Institute: Department of Medicine, Georgetown University, Washington

Instrument:

Aperio GT 450
Authors: Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST.
Study Goals: To demonstrate the detection of early precancerous lesions (PanINs) in genetically engineered mice.
Keywords: Aperio GT450, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs
   
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Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A.

Publication Year: 2021
Country: USA
PMID: PMC8774279
Publication: Toxicology Research and Application. 2021;5:239784732110471. doi:10.1177/23978473211047164
Institute: Mechanistic Toxicology Branch, Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), 111 TW Alexander Drive, Research Triangle Park, NC 27709

Instrument:

Aperio AT2
Authors: Castro L, Liu J, Yu L, et al.
Study Goals: To show that RTKs are dysregulated following early life TBBPA exposures and their sustained activation may contribute to TBBPA-induced uterine tumors observed in rats later in life.
Keywords: Aperio AT2
   
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A single-cell-type transcriptomics map of human tissues.

Publication Year: 2021
Country: Sweden
PMID: PMC8318366
Publication: Nature Genetics. 2021;53(9):1275-1275. doi:10.1038/s41588-021-00938-4
Institute: Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology, Stockholm

Instrument:

Aperio AT2
Authors: Alam O.
Study Goals: To create a a high-resolution single–cell type map of human tissues.
Keywords: Aperio AT2
   
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Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.

Publication Year: 2021
Country: USA
PMID: PMC8848646
Publication: BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3
Institute: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Instrument:

Aperio AT2
Authors: Delahoussaye AM, Abi Jaoude J, Green M, et al.
Study Goals: To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer.
Keywords: Aperio AT2
   
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Ls-citation

Deep Learning of Histopathology Images at the Single Cell Level.

Publication Year: 2021
Country: USA
PMID: PMC8461055
Publication: Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641
Institute: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Instrument:

Aperio AT2
Authors: Lee K, Lockhart JH, Xie M, et al.
Study Goals: To systematically  review the various machine learning methods with a focus on cell-level analysis.
Keywords: Aperio AT2
   
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Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging.

Publication Year: 2021
Country: UK
PMID: PMC8073208
Publication: Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506
Institute: Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB

Instrument:

Aperio CS2
Authors: Flint LE, Hamm G, Ready JD, et al.
Study Goals: To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques.
Keywords: Aperio CS2
   
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Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats.

Publication Year: 2021
Country: Taiwan
PMID: PMC8236591
Publication: Frontiers in Neural Circuits. 2021;15. doi:10.3389/fncir.2021.693073
Institute: Department of Life Science, National Taiwan University, Taipei

Instrument:

Aperio CS2
Authors: Kuo C-W, Chang M-Y, Liu H-H, et al.
Study Goals: To demonstrate a novel CES scheme with a theta-burst stimulation (TBS) protocol to identify the therapeutic potential of cortical electrical stimulation (CES) in a weight drop-induced rat model of traumatic brain injury (TBI).
Keywords: Aperio CS2
   
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Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors.

Publication Year: 2021
Country: Taiwan
PMID: PMC7864566
Publication: Science Advances. 2021;7(6). doi:10.1126/sciadv.abd0772
Institute: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan

Instrument:

Aperio CS2
Authors: Chen K-T, Chai W-Y, Lin Y-J, et al.
Study Goals: To provide evidence of focused ultrasound (FUS)-induced immune modulation as an additional therapeutic benefit by converting the immunosuppressive  tumor microenvironment  (TME) into an immunostimulatory TME via a higher but safe FUS dosage.
Keywords: Aperio CS2
   
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Cardioprotective Effects of Palmitoleic Acid (C16:1n7) in a Mouse Model of Catecholamine-Induced Cardiac Damage Are Mediated by PPAR Activation.

Publication Year: 2021
Country: Germany
PMID: PMC8657733
Publication: International Journal of Molecular Sciences. 2021;22(23):12695. doi:10.3390/ijms222312695
Institute: Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10115 Berlin

Instrument:

Aperio CS2
Authors: Betz IR, Qaiyumi SJ, Goeritzer M, et al.
Study Goals: C16:1n7 might have protective effects on cardiac fibrosis and inflammation. 
Keywords: Aperio CS2
   
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Ls-citation

Deep Learning of Histopathology Images at the Single Cell Level.

Publication Year: 2021
Country: USA
PMID: PMC8461055
Publication: Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641
Institute: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Instrument:

Aperio Versa
Authors: Lee K, Lockhart JH, Xie M, et al.
Study Goals: To systematically  review the various machine learning methods with a focus on cell-level analysis.
Keywords: Aperio Versa, histopathology image analysis, deep learning, image data labeling, cell type classification, tumor immune microenvironment, tumor heterogeneity
   
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NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice.

Publication Year: 2021
Country: China
PMID: PMC8535822
Publication: Science Advances. 2021;7(43). doi:10.1126/sciadv.abi9471
Institute: State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital of Xiamen University, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102,

Instrument:

Aperio Versa
Authors: Zhang P, Liu Y, Hu L, et al.
Study Goals: To study NLRC4-mediated cell death and tissue damage
Keywords: Aperio Versa
   
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Ls-citation

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.

Publication Year: 2021
Country: USA
PMID: PMC8554823
Publication: ACS Central Science. 2021;7(10):1638-1649. doi:10.1021/acscentsci.1c00529
Institute: Department of Radiology and Biomedical Imaging

Instrument:

Aperio Versa
Authors: Zhao N, Bardine C, Lourenço AL, et al.
Study Goals: To evaluate whether granzyme biochemistry can be assessed in vivo using an imaging modality that can be scaled vertically into human subjects
Keywords: Aperio Versa
   
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Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models.

Publication Year: 2021
Country: USA
PMID: PMC8561005
Publication: iScience. 2021;24(11):103245. doi:10.1016/j.isci.2021.103245
Institute: Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco

Instrument:

Aperio Versa
Authors: Das M, Mao W, Shao E, et al.
Study Goals: To understand whether Increased expression of TREM2 seems to support microglial activities that counteract AD related network dysfunction
Keywords: Aperio Versa
   
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Ls-citation

Computational Model-Based Estimation of Mouse Eyeball Structure From Two-Dimensional Flatmount Microscopy Images.

Publication Year: 2021
Country: USA
PMID: PMC8088229
Publication: Translational Vision Science & Technology. 2021;10(4):25. doi:10.1167/tvst.10.4.25
Institute: Department of Mathematics and Statistics, Georgia State University, Atlanta, GA

Instrument:

Imagescope/Aperio Software
Authors: Li H, Yu H, Kim Y-K, et al.
Study Goals: To investigate a  a new method for estimating the three-dimensional (3D) eyeball sphere from two-dimensional tissue flatmount microscopy images
Keywords: Aperio CS2
   
Image
Ls-citation

Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging.

Publication Year: 2021
Country: UK
PMID: PMC8073208
Publication: Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506
Institute: Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB

Instrument:

Imagescope/Aperio Software
Authors: Flint LE, Hamm G, Ready JD, et al.
Study Goals: To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques.
Keywords: Aperio CS2
   
Image
Ls-citation

Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas.

Publication Year: 2021
Country: USA
PMID: PMC8698999
Publication: Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766
Institute: Department of Medicine, Georgetown University, Washington

Instrument:

Imagescope/Aperio Software
Authors: Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST.
Study Goals: To demonstrate  the detection of early precancerous lesions (PanINs) in genetically engineered
mice.
Keywords: Aperio AT2, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs
   

Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.

Publication Year: 2021
Country: USA
PMID: PMC8848646
Publication: BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3
Institute: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Instrument:

BOND RX
Authors: Delahoussaye AM, Abi Jaoude J, Green M, et al.
Study Goals: To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer.
Keywords: BOND RX, Gemcitabine; KPC mice; Nab-paclitaxel; Pancreatic cancer; SBRT; mFOLFIRINOX
   

Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.

Publication Year: 2021
Country: New Zealand
PMID: PMC8017302
Publication: Frontiers in Surgery. 2021;8. doi:10.3389/fsurg.2021.621089
Institute: Gillies McIndoe Research Institute, Wellington

Instrument:

BOND RX
Authors: Luke Krishnan CS, Brasch HD, Patel J, et al.
Study Goals: Investigated the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial AVM
Keywords: BOND RX
   

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