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Pre-Analytics and Histology Research Solutions

Tissue-Based Research Workflows: Why Quality Matters

Quality, once lost, cannot be regained. Upstream pre-analytic quality is imperative to generating high-caliber data for exploring spatial biology, from IHC to multiplexing to plotting the tumor microenvironment.

A good quality process lays the foundation for quality research results. Leica Biosystems recognizes the importance of focusing on “why quality matters” throughout the workflow cascade of tissue-based research and its impact on downstream results. Optimizing efficiencies can help build trustworthiness, improve quality, and impact downstream staining applications.

When designing a research project plan or building a new laboratory, one must learn how to assess each step of the pre-staining process with an eye to quality that can create repeatable and reliable results.

  • An essential step in good quality staining of a tissue specimen is through fixation and subsequent tissue processing.
  • Consistency in tissue section thickness, and the chemistry of tissue adherence to slides is crucial in producing the most intact and reliable morphological specimens that are required for high-quality staining.

Tissue Processing


Rapid Processing. Proven Quality.

Biopsies, resections, or fatty specimens; different tissues need different treatments. The scalable range of single or dual retort processors deliver optimized processing for each sample without slowing down your research laboratory.

In a research laboratory no two days are ever the same. Establish and adapt a workflow to meet the demands of your laboratory every day, with short cycle times and flexible processing protocols. In-built intelligent automation helps prevent user error to improve efficiency and maximize productivity.

Learn how to optimize your tissue processing workflow by:

  • Implementing best laboratory practices
  • Optimizing and enhancing histology workflow protocols and using quality reagents and consumables
  • Minimize the need for repeat downstream testing

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Here are some resources we’ve chosen for you:


Lessons from the Laboratory: Optimizing Your Tissue Processing

In this webinar, Robin Fitzl, Senior Field Applications Specialist at Leica Biosystems, shares her insights and tips on proper tissue processing.

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Tissue Processing Artifacts: Checklist for Success

Learn more about tissue processing artifacts, what is "optimal" and what is "not," and how to optimize tissue processing techniques.

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Tissue Processing: A Cornerstone to Quality Downstream Testing

As immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurately interpreting disease processes.

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Make Critical Discoveries Sooner with Leica Biosystems Cryosectioning Solutions

Research environments require flexibility and adaptability for sectioning diverse tissues and materials.

Cryo-sectioning is often the preferred methodology, providing superior antigenicity, and more accurate detection of antigens in downstream applications. Automation has changed the game in cryosectioning, offering reproducibility and high-quality sectioning over the manual method.

  • Benefit from reproducible results for molecular analysis
  • Quality and precision in sample preparation are crucial for intact RNA, DNA and protein retrieval
  • Prepare and preserve morphology, genetic material, and antigenicity with a simple and flexible solution

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Here are some resources we’ve chosen for you:

Histology Hacks for Cryosectioning

Research environments require flexibility and adaptability for sectioning diverse tissues and materials. Cryosectioning is often the preferred methodology, providing superior antigenicity and more.

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Cryosectioning 101 for Research Q&A

Questions included in the document are advice on tissue tearing, keeping samples at a low temperature when working and preference for high, or low-profile blades.

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Tips for Choosing an Embedder

When choosing an embedder, three areas should be considered to maximize your purchase: Simple Operation, Smooth Workflow and Precise Control.

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Research Microtomy


Preparing tissue specimens for histological examination requires care, skill and sound procedures. Broaden your research with a wide selection of blade and specimen holders enabling you to discover new breakthroughs in research for biomedical to industrial applications.

  • Benefit from customized settings for comfort and efficiency
  • Prepare high quality, non-human paraffin sections for all your research needs
  • Achieve faster trimming and consistent cuts

The new portfolio of Research Microtomes facilitates faster trimming with new coarse feed wheel options allowing you to customize the direction of rotation.

Reach out for a consultation!

Here are some resources we’ve chosen for you:

Research Microtome Comparison Guide

What are the important features when choosing a microtome? Here is an easy-to-use microtome guide to help you through the process.

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4 Tips for Buying a Microtome

What should you look for when purchasing a microtome? Here, we offer 4 tips that will help you through the process.

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Research Microtome Buying Guide

Reliable and precise microtomes are designed to provide high-quality sections and enhanced efficiency.

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Selected Solutions for your Research Needs

Leica Biosystems can help you build quality into your research projects with integrated and optimized instruments and solutions. We want to be your end-to-end partner in building quality into and throughout your tissue-based research.

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For research use only. Not for use in diagnostic procedures.

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