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Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma are among the most common malignant soft tissue tumors presented in older adults. These tumors can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas. Amplification of the MDM2 gene has been identified in lipomatous neoplasms. The use of fluorescence in situ hybridization in identifying MDM2 amplification has made the...