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The t(12;21), a cryptic translocation rarely observed by conventional cytogenetics, was first identified by fluorescence in situ hybridization (FISH). In ALL blasts, this translocation fuses the 5' part of the ETV6 (previously known as TEL) gene with almost the entire RUNX1 (previously known as AML) (CBFA2) gene, producing the chimeric transcript ETV6-CBFA2. The t(12;21) (p13;q22) has also been identified as the most frequent chromosomal abnormal...
Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma are among the most common malignant soft tissue tumors presented in older adults. These tumors can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas. Amplification of the MDM2 gene has been identified in lipomatous neoplasms. The use of fluorescence in situ hybridization in identifying MDM2 amplification has made the...