MitPro: Next-Generation Mitosis Profiling
MitPro is an AI-driven solution that analyses H&E-stained tissue slides to identify mitotic figures, supporting faster mitosis counting and reducing variability across pathologists. It processes the entire slide, identifies the three highest-scoring hotspots, and allows verification of results. If desired, MitPro will also perform counting in manually defined hotspots.
MitPro is applicable to a range of samples from human cancers, including breast, lung, melanoma (including uveal melanoma), soft tissue sarcomas, leiomyoma, NETs, glioblastoma, meningioma, thyroid, and retinoblastoma.
MitPro is For Research Use Only and not intended for clinical diagnostic use. MitPro accessed via the Aperio HALO AP image management system.
Zoom image Step 1: Mitotic Figure Detection & Hotspot Identification
MitPro is compatible with H&E images from a wide range of cancer types.
Processing begins immediately after scanning, ensuring that results are ready for review as soon as the pathologist opens the case in HALO AP.
The algorithm identifies all mitotic figures across the tissue and determines the three regions (hotspots) with the highest counts. A score is provided for each hotspot.
Step 2: Hotspot selection
Pathologists can choose to perform counting in any of the three automatically suggested hotspots. If these are not appropriate, they may define one or more custom hotspots directly in the viewer, which are then used for counting.
By default, a circular hotspot of 2 mm² is provided. For melanoma samples, however, the hotspot is defined as 1 mm², and in core biopsies it is adapted to match the shape of the tissue.
In this example, the hotspot with the most mitotic figures (hotspot 1) is selected.
Step 3: Mitotic figure verification
Within either the suggested or custom hotspot(s), the pathologist reviews the detected mitotic figures and can confirm, add, or remove them as needed. The following results are then reported:
- Count
- Area (mm²)
- Density (count/mm²)
Seamless Integration
MitPro enhances mitosis counting in H&E-stained images while fitting naturally into existing digital pathology workflows. Fully integrated with the Aperio HALO AP, MitPro brings AI-driven insights directly into routine practice - supporting pathologists with faster, more consistent, and reproducible results.
