ACD – a Bio-Techne brand is a pioneer and leader in the advancement of spatial genomics by unlocking the power of RNA and developing cell- and tissue-based research.
ACD’s proprietary technology, RNAscope, is the gold standard for RNA in situ hybridization, trusted by top academic institutions, pharmaceutical companies, and service providers around the world. Backed by over 13,000 peer-reviewed publications, RNAscope delivers single-molecule sensitivity with high target specificity in morphological context.
RNAscope 2.5 LS and LSx, Red and Brown assays are automated solutions that enable customers to achieve high-throughput detection of RNA targets using the BOND RX research staining platform. With both protease and protease-free workflow options, these assays enable the seamless integration of RNA ISH and downstream IHC protein detection for a high-throughput multiomic assay.
The RNAscope 2.5 LS Duplex assay enables the simultaneous detection of two RNA targets for co-localization studies. Visualize a secreted ligand and its receptor, or profile gene expression in a specific cell type expressing a known marker, such as a stem cell marker.
The RNAscope Multiomic LS assay enables highly sensitive and specific detection of both RNA and proteins in the same tissue section for a true multiomic spatial assay. Proven RNAscope technology is leveraged along with a protease-free workflow to enable the simultaneous detection of up to six total proteins and RNA targets with single-cell resolution. Available RNAscope primary antibodies against common targets and RNAscope secondary antibodies used with one’s own primaries can be combined with RNAscope probes to quickly build a custom multiomic assay.
The ProximityScope assay is designed to reveal functional protein-protein interactions within intact tissues, delivering a spatial solution to explore how molecular signaling shapes disease processes. The assay is designed to produce a positive signal when two proteins of interest are in proximity. This allows researchers to uncover biological mechanisms, assess treatment responses for patient stratification, optimize therapeutic development, and study alterations in the tissue microenvironment.
For Research Use Only. Not for use in diagnostic procedures.
