The Leica Biosystems Process and Solutions Optimization team has partnered with Wisconsin Diagnostics to evaluate and optimize efficiency through automation. For this study, the HistoCore SPECTRA ST H&E staining system was utilized with two different platforms. The HistoCore SPECTRA ST Stainer, with detached Leica CV5030 Coverslipper, was compared with the HistoCore SPECTRA CV coverslipper, offering attached and automated coverslipping.