Prostate AI
Developed by Indica Labs, the Prostate AI solution leverages deep learning technology to standardize the scoring of H&E stained prostate core needle biopsy samples. The algorithm reports quantitative results and markup images, including tumor localization, size and Gleason scores.
Prostate AI is For Research Use Only and not intended for clinical diagnostic use. Prostate AI accessed via the Aperio HALO AP image management system.
Bild vergrößern Step 1: H&E Prostate Image
Prostate AI is a deep learning tool to standardize the scoring of H&E stained prostate core needle biopsy samples.
The algorithm can be launched by a user directly in the viewer or configured to automatically run for every prostate biopsy image in Aperio HALO AP.
Step 2: Tumor Detection Classifier
An image analysis heatmap mask is generated for each slide, denoting regions within the biopsy with a high probability of cancer shown as orange to red (85-100% probability).
The following metrics are calculated as outputs for each slide:
- Classified Area
- Background Area
- Tumor Area
- Tumor Detected: Yes/No
- % Tumor area
Step 3: Gleason Scoring Classifier
The Gleason Scoring classifier generates an image analysis mask for each slide, denoting the following regions:
- Gleason Pattern 3: Yellow
- Gleason Pattern 4: Orange
- Gleason Pattern 5: Red
Results: Slide Metrics
The Gleason Scoring classifier generates the following metrics as outputs at the slide level:
- Grade Group
- % Gleason Pattern 3 Area
- % Gleason Pattern 4 Area
- % Gleason Pattern 5 Area
- Classified Area
- Gleason Pattern 3 Area
- Gleason Pattern 4 Area
- Gleason Pattern 5 Area
- Mucinous Area
- IDC-P Area
- HGPIN Area
- Benign Area
Results: Case Metrics
Ultimately, Prostate AI calculates the following metrics as outputs at the case level:
- The Cumulative grade group is reported for the case.
- The Maximal grade group is reported for the case.
- Results can also be viewed as a published PDF report.
Prostate AI in Aperio HALO AP Demonstration
Explore the future of pathology with the Prostate AI app from Indica Labs. Prostate AI seamlessly integrates within the Aperio HALO AP enterprise digital pathology platform to identify tumor rich regions for Gleason Grading in prostate cancer samples.
After selecting a case, view the H&E slides assigned to that case in the viewer and the Prostate AI results. Results include two overlays and quantitative results. The first overlay identifies tumor rich areas of the tissue. The second overlay identifies the Gleason scoring patterns within the tumor area. Finally, quantitative results at a per slide and case level are displayed in the assay panel to the right.
Documents
Flyer - Indica Labs Clinical AI
Size: 2.05 MB,
Typ: pdf
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