Prostate AI is a deep learning tool to standardize the scoring of H&E stained prostate core needle biopsy samples.

The algorithm can be launched by a user directly in the viewer or configured to automatically run for every prostate biopsy image in Aperio HALO AP.

An image analysis heatmap mask is generated for each slide, denoting regions within the biopsy with a high probability of cancer shown as orange to red (85-100% probability).

The following metrics are calculated as outputs for each slide:

• Classified Area
• Background Area
• Tumor Area
• Tumor Detected: Yes/No
• % Tumor area

The Gleason Scoring classifier generates an image analysis mask for each slide, denoting the following regions:

• Gleason Pattern 3: Yellow
• Gleason Pattern 4: Orange
• Gleason Pattern 5: Red

The Gleason Scoring classifier generates the following metrics as outputs at the slide level:

• Grade Group
• % Gleason Pattern 3 Area
• % Gleason Pattern 4 Area
• % Gleason Pattern 5 Area
• Classified Area
• Gleason Pattern 3 Area
• Gleason Pattern 4 Area
• Gleason Pattern 5 Area
• Mucinous Area
• IDC-P Area
• HGPIN Area
• Benign Area

Ultimately, Prostate AI calculates the following metrics as outputs at the case level:

• The Cumulative grade group is reported for the case.
• The Maximal grade group is reported for the case.
• Results can also be viewed as a published PDF report.