Skip to main content

Characterization of the Pancreatic Tumor Microenvironment using Novel Quantitative Multiplex DSP

Dr. Dana Adel Mustafa
Dr. Dana Adel Mustafa Assistant Professor & Group leader of the Tumor Immuno-Pathology (TIP) Laboratory Erasmus University Medical Center, Department Pathology

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease associated with poor outcomes. So far, the factors and pathways underlying patient survival in PDAC are unknown. However, the location, number, and characterization of immune cells that infiltrate PDAC tissue provide crucial information.

In this webinar, Dr. Dana Adel Mustafa, assistant professor and group leader of the Tumor Immuno-Pathology (TIP) Laboratory at Erasmus University Medical Center, shares how using the GeoMx® Digital Spatial Profiler (DSP) to measure PDAC tissue samples can reveal the key immune-related players that drive survival in PDAC patients. Mustafa explains how this technology enabled high-plex proteomic analysis of formalin-fixed, paraffin-embedded samples with spatial resolution. Mustafa also shares that higher B cell infiltration in PDAC tissue samples is associated with higher infiltration of T cells and higher antigen presentation, resulting in better prognoses.

Learning Objectives

  • Learn how to extract the maximum information using the minimum amount of samples
  • Understand why we need more than just numbers to tell the whole story
  • Appreciate how precise tissue navigation leads to precise medicine

About the presenter

Dr. Dana Adel Mustafa
Dr. Dana Adel Mustafa , Assistant Professor & Group leader of the Tumor Immuno-Pathology (TIP) Laboratory Erasmus University Medical Center, Department Pathology

Dana Adel Mustafa is a biologist and a cancer researcher at Erasmus medical Center, Rotterdam, The Netherlands. She mainly studies two of the most deadly cancers: pancreatic cancer and brain tumors. Her research aims to reveal the immune regulation and infiltration in various types of cancers. In addition, her group focuses in identifying circulating biomarkers for detecting the response to therapy. She is interested in cancer metabolism, and in connecting the metabolic and genomics maps. She has been using various -omics technologies to identify the new prevention targets. Following by the state-of-the-art organ-on-a chip and organoid models to validate the usefulness of the new discoveries. Working with and for people like patients and students is dr. Mustafa's drive. Therefore, she became an assistant professor and a group leader of the Tumor Immuno-Pathology (TIP) lab in 2017. She became a member of a big consortium of Oncolytic Viro-Immune therapy (OVIT) to create new therapeutic options for cancer patients. Dr. Mustafa strongly believe that we can make progress in the battle against this disease by extensive collaboration between various people, disciplines and institutions.

Related Content

Leica Biosystems content is subject to the Leica Biosystems website terms of use, available at: Legal Notice. The content, including webinars, training presentations and related materials is intended to provide general information regarding particular subjects of interest to health care professionals and is not intended to be, and should not be construed as, medical, regulatory or legal advice. The views and opinions expressed in any third-party content reflect the personal views and opinions of the speaker(s)/author(s) and do not necessarily represent or reflect the views or opinions of Leica Biosystems, its employees or agents. Any links contained in the content which provides access to third party resources or content is provided for convenience only.

For the use of any product, the applicable product documentation, including information guides, inserts and operation manuals should be consulted.

Copyright © 2024 Leica Biosystems division of Leica Microsystems, Inc. and its Leica Biosystems affiliates. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH.