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H&E is an important tool for disease research and drug development and is being increasingly combined with digital pathology technology. Image quality is important for slide digitization to ensure that interpretation is accurate. Take a look at some images here, produced by our digital pathology scanners.

In the webinar Cryosectioning 101 for Research, John Stock provided a comprehensive guide on achieving better cryosectioning outcomes. John went on to answer customer questions at the end of the session, that have been compiled for your viewing here.

Antigen BackgroundEstrogen receptor (ER) content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. The introduction of highly specific monoclonal antibodies to ER has allowed the determination of receptor status of breast tumors to be carried out in routine histopathology laboratories.Product Specific InformationClone 6F11 is raised to the full length alpha form of the estrogen rec...

Antigen BackgroundProgrammed death-ligand 1 (PD-L1), CD274 or B7 Homolog 1(B7-H1) is a protein encoded by the CD274 gene. When bound to its ligands, PD-1 and B7.1, it plays an immunosuppressive role by inhibiting T-cell activity. Overexpression of PD-L1 by cancer cells may enable them to evade the host immune response, conferring a growth advantage to such tumours. PD-L1 expression levels detected by immunohistochemistry can therefore be of progn...

Antigen BackgroundClone 22C9 reacts with the gamma subunit of the enolase isoenzyme. DisclaimerNeuron Specific Enolase is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Antigen Background In some tissues, non-specific binding may occur, especially in neoplastic or necrotic tissue. Product Specific Information Negative Control is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.  

CV Ultra has been developed to replace Xylene/Toluene and conventional mounting media in histopathology/cytopathology laboratories. It is used for coverslipping (mounting). The use of CV Ultra is extremely flexible. CV Ultra can be used with Xylene and Toluene. For all common robotic coverslippers as well as for manual coverslipping procedures. This coverslipping reagent does not contain any dangerous organic solvents....

Antigen Background Intracellular muramidase, also known as lysozyme, has been reported to be expressed in myeloid and monocytic cells, in leukocytes and in myelo-proliferative disorders. Muramidase is also reported to be expressed in poorly differentiated leukemic monoblasts. Disclaimer Lysozyme (Muramidase) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopatho...