158 result(s) for 'Antibodies'
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Antigen Background
Myosin is a contractile muscle specific protein composed of two heavy and four light chains. The myosin heavy chain has many isoforms which are specific for different muscles or fiber types, some of which are developmentally regulated. The range of myosin heavy chain antibodies may prove useful for investigating development of intrafusal and extrafusal muscle fibers and the course of muscle fiber regeneration. At the ultrastruc...
Antigen Background
Duchenne Muscular dystrophy (DMD) is the most common of the muscular dystrophies resulting in progressive muscular wasting and death. Dystrophin is the 427kD protein product of the DMD gene located on the X chromosome at position Xp21. Abnormalities in protein expression occur in patients with DMD/BMD and dystrophin analysis may be used to distinguish these conditions from other neuromuscular diseases. Severe Duchenne muscular ...
Antigen Background The gene responsible for LGMD2A has been identified as the chromosome 15q15-encoded muscle-specific
calcium-activated neutral protease, calpain 3. Calpain 3 enzyme is only stable in human muscle when homogenized in treatment buffer immediately after harvest (Anderson LVB et al. Am. J. of Pathol. 153(4), 1169-1179 (1998)), and in homogenates
containing SDS and is therefore well suited for analysis by Western blot. NCL-CALP-2C4 r...
Novocastra Antibodies
Create high-quality IHC slides with Novocastra primary antibodies. Developed in-house, and backed by 20 years of IHC stain development experience, these robust antibodies have been optimized for automated and manual applications. Spanning 14 pathology menus, Leica Biosystems offers laboratories a comprehensive range of clinically relevant antibodies for the most demanding workload.
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Antigen Background
IgM, together with IgD, is the major immunoglobulin expressed on the surface of B cells and normally constitutes about 10 per cent of serum immunoglobulin. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as natural blood group antibodies.
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Immunoglobulin M is recommended for the detection of specific antigens of interest in normal and neoplastic ...
Antigen Background
IgA is a member of the antibody class of the immunoglobulin superfamily. There are several classes and subclasses (isotypes) of antibody, the antibody isotype being defined by the immunoglobulin heavy chain present in the molecule. The basic structure of an immunoglobulin molecule consists of two identical heavy chains (gamma , mu, alpha , delta , epsilon) and two identical light chains, either kappa or lambda. IgA contains the...