 |
Unravelling New Roles Of A Tomato SIN3 Homolog In Leaf Polarity Mediated By Auxin Signaling And Leaf Growth-Related Transcription Factors
| Publication Year: |
2022 |
| Country: |
China |
| PMID: |
N/A |
| Publication: |
Scientia Horticulturae. 2022;300:111055. doi:10.1016/j.scienta.2022.111055 |
| Institute: |
Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang A&F University, Hangzhou 311300, Zhejiang |
|
Instrument:
|
Leica HistoCore NANOCUT R |
| Authors: |
Liu Y, Fei S, Chen Y, et al. |
| Study Goals: |
To explore a new role of SIN3 in leaf polarity and provide a possible action mechanism of SlSIN3a in leaf development. |
| Keywords: |
Tomato, SIN3, Leaf development, Adaxial–abaxial polarity, Leica HistoCore NANOCUT R |
| |
|
|
|
A Previously Unknown Feeding Mode In Millipedes And The Convergence Of Fluid Feeding Across Arthropods
| Publication Year: |
2022 |
| Country: |
Germany |
| PMID: |
PMC8849289 |
| Publication: |
Science Advances. 2022;8(7). doi:10.1126/sciadv.abm0577 |
| Institute: |
Zoological Research Museum Alexander Koenig, Leibniz Institute for the Analysis of Biodiversity Change, Section Myriapoda, Adenauerallee 160, 53113 Bonn |
|
Instrument:
|
Leica HistoCore NANOCUT R |
| Authors: |
Moritz L, Borisova E, Hammel JU, Blanke A, Wesener T. |
| Study Goals: |
To trace the evolution of suctorial feeding in arthropods. |
| Keywords: |
Arthropods, Diplopoda, Pumping chamber, Fluid feeding, Leica HistoCore NANOCUT R |
| |
|
|
|
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression
| Publication Year: |
2022 |
| Country: |
USA |
| PMID: |
PMC8955233 |
| Publication: |
Viruses. 2022;14(3):535. doi:10.3390/v14030535 |
| Institute: |
Louisiana Animal Disease Diagnostic Laboratory (LADDL), Louisiana State University, Baton Rouge, LA 61329 |
|
Instrument:
|
BOND RXm |
| Authors: |
Carossino M, Kenney D, O’Connell AK, et al. |
| Study Goals: |
To analyse neuroinvasion and neurodissemination in humans call into question the translational relevance of this model. |
| Keywords: |
BOND RXm, translational animal model; comparative pathology; immunohistochemistry; in situ hybridization; viral pathogenesis; transmission electron microscopy; in vivo imaging |
| |
|
|
|
|
Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.
| Publication Year: |
2022 |
| Country: |
USA |
| PMID: |
PMC8340647 |
| Publication: |
Frontiers in Immunology. 2021;12. doi:10.3389/fimmu.2021.713420 |
| Institute: |
Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC |
|
Instrument:
|
Aperio GT 450 |
| Authors: |
Suresh M, Li B, Murreddu MG, Gudima SO, Menne S. |
| Study Goals: |
To show that the the differential expression of PRRs during resolution and persistence of WHV infection emphasizes their importance in the ultimate viral control during AHB that is impaired during CHB. |
| Keywords: |
Aperio GT450 |
| |
|
|
|
An Injectable Mesoporous Silica-Based Analgesic Delivery System Prolongs The Duration Of Sciatic Nerve Block In Mice With Minimal Toxicity
| Publication Year: |
2021 |
| Country: |
China |
| PMID: |
34520884 |
| Publication: |
Acta Biomaterialia. 2021;135:638-649. doi:10.1016/j.actbio.2021.09.008 |
| Institute: |
Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yi Shan Road, Shanghai 200233 |
|
Instrument:
|
Leica HistoCore NANOCUT R |
| Authors: |
Wang H, Zhang Y, Xu X, Wang A. |
| Study Goals: |
To demonstrate the potential of the mesoporous silica-based analgesic nanocomposites in effectively controlling postoperative pain |
| Keywords: |
Postoperative pain management, Long-lasting anesthetics, Mesoporous silica Injectable nanocomposite, Leica HistoCore Nanocut R |
| |
|
|
|
A Tarsal Spinning Organ In Glomeridesmid Millipedes (Diplopoda: Pentazonia: Glomeridesmida)
| Publication Year: |
2021 |
| Country: |
Germany |
| PMID: |
N/A |
| Publication: |
Arthropod Systematics & Phylogeny. 2021;79:555-567. doi:10.3897/asp.79.e70002 |
| Institute: |
Zoological Research Museum Alexander Koenig, Leibniz Institute for Animal Biodiversity, Adenauerallee 160, 53113 Bonn |
|
Instrument:
|
Leica HistoCore NANOCUT R |
| Authors: |
Moritz L, Wesener T. |
| Study Goals: |
To describe thread-producing glands from the species-poor Glomeridesmida |
| Keywords: |
Exocrine gland, Glomeridesmus, leg, Limacomorpha, scanning electron microscopy, silk, spinnerets, Termitodesmus, Leica HistoCore NANOCUT R |
| |
|
|
|
CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
N/A |
| Publication: |
Scientific Reports. 2021;11(1). doi:10.1038/s41598-021-96979-0 |
| Institute: |
Fred Hutchinson Cancer Research Center, University of Washington, Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute |
|
Instrument:
|
BOND RX |
| Authors: |
Eichholz K, Li AZ, Diem K, Jensen MC, Zhu J, Corey L. A |
| Study Goals: |
A CAR RNA FISH histo-cytometry platform combined with a random reaction seed image analysis algorithm to quantitate spatial distribution and in vivo functional activity of a CAR T cell population at a single cell resolution for preclinical models. |
| Keywords: |
BOND RX, Chimeric antigen receptor, (CAR) T, CAR RNA FISH, histo-cytometry |
| |
|
|
|
A non-clinical comparative study of IL-23 antibodies in psoriasis
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
34460338 |
| Publication: |
mAbs. 2021;13(1). doi:10.1080/19420862.2021.1964420 |
| Institute: |
Abbvie Bioresearch Center, Worcester |
|
Instrument:
|
BOND RX |
| Authors: |
Zhou L, Wang Y, Wan Q, et al. |
| Study Goals: |
To investigate if four clinically approved antibodies targeting IL-23 differ in affinity and binding epitope |
| Keywords: |
BOND RX, IL-23, IL-12, psoriasis, autoimmune disease, risankizumab, guselkumab, tildrakizumab, ustekinumab |
| |
|
|
|
Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model
| Publication Year: |
2021 |
| Country: |
France |
| PMID: |
PMC8376007 |
| Publication: |
PLOS Pathogens. 2021;17(8):e1009427. doi:10.1371/journal.ppat.1009427 |
| Institute: |
Ecole nationale vétérinaire de Toulouse, ENVT, INRAE, UMR 1225, IHAP, Université de Toulouse, Toulouse |
|
Instrument:
|
BOND RXm |
| Authors: |
Bessière P, Wasniewski M, Picard-Meyer E, et al. |
| Study Goals: |
To investigate whether early type I IFN treatment is beneficial, while late interventions are ineffective, although not associated with signs of enhanced disease. |
| Keywords: |
BOND RXm |
| |
|
|
|
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC7930198 |
| Publication: |
Nature Communications. 2021;12(1). doi:10.1038/s41467-021-21615-4 |
| Institute: |
Fred Hutchinson Cancer Research Center, Seattle, WA |
|
Instrument:
|
BOND RXm |
| Authors: |
Brady L, Kriner M, Coleman I, et al. |
| Study Goals: |
To demonstrate the utility of digital spatial profiling for accurately classifying tumor phenotype, assessing tumor heterogeneity, and identifying aspects of tumor biology involving the immunological composition of metastases. |
| Keywords: |
BOND RXm, metastatic prostate cancer, tumor heterogeneity, tumor phenotype, digital spatial profiling (DSP), multiplex |
| |
|
|
|
Immunohistochemical Characterization of a Duodenal Adenocarcinoma with Pulmonary, Hepatic and Parapatellar Metastases in a Common Marmoset (Callithrix jacchus)
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
N/A |
| Publication: |
Journal of Comparative Pathology |
| Institute: |
Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, Maryland |
|
Instrument:
|
BOND RXm |
| Authors: |
Peterson C, Plunkard J, Johanson A, Izzi J, Gabrielson K. |
| Study Goals: |
To investigate proximal duodenal adenocarcinoma with extensive metastatic disease in a common marmoset |
| Keywords: |
BOND RXm, common marmoset; duodenal mucinous adenocarcinoma; metastases; pancytokeratin |
| |
|
|
|
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
| Publication Year: |
2021 |
| Country: |
UK |
| PMID: |
PMC8187652 |
| Publication: |
Nature Communications. 2021;12(1). doi:10.1038/s41467-021-23717-5 |
| Institute: |
Cancer Research UK Beatson Institute, Glasgow |
|
Instrument:
|
BOND RX |
| Authors: |
Leach JDG, Vlahov N, Tsantoulis P, et al. |
| Study Goals: |
To study a mouse model of right-sided colon cancer driven by oncogenic BRAF and loss of epithelial TGFβ-receptor signalling |
| Keywords: |
BOND RX, colorectal cancer, oncogenic BRAF, epithelial TGFβ-receptor signaling, RNAscope, Multiplex |
| |
|
|
|
|
Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8698999 |
| Publication: |
Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766 |
| Institute: |
Department of Medicine, Georgetown University, Washington |
|
Instrument:
|
Aperio GT 450 |
| Authors: |
Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST. |
| Study Goals: |
To demonstrate the detection of early precancerous lesions (PanINs) in genetically engineered mice. |
| Keywords: |
Aperio GT450, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs |
| |
|
|
|
|
Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8774279 |
| Publication: |
Toxicology Research and Application. 2021;5:239784732110471. doi:10.1177/23978473211047164 |
| Institute: |
Mechanistic Toxicology Branch, Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), 111 TW Alexander Drive, Research Triangle Park, NC 27709 |
|
Instrument:
|
Aperio AT2 |
| Authors: |
Castro L, Liu J, Yu L, et al. |
| Study Goals: |
To show that RTKs are dysregulated following early life TBBPA exposures and their sustained activation may contribute to TBBPA-induced uterine tumors observed in rats later in life. |
| Keywords: |
Aperio AT2 |
| |
|
|
|
|
A single-cell-type transcriptomics map of human tissues.
| Publication Year: |
2021 |
| Country: |
Sweden |
| PMID: |
PMC8318366 |
| Publication: |
Nature Genetics. 2021;53(9):1275-1275. doi:10.1038/s41588-021-00938-4 |
| Institute: |
Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology, Stockholm |
|
Instrument:
|
Aperio AT2 |
| Authors: |
Alam O. |
| Study Goals: |
To create a a high-resolution single–cell type map of human tissues. |
| Keywords: |
Aperio AT2 |
| |
|
|
|
|
Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8848646 |
| Publication: |
BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3 |
| Institute: |
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
|
Instrument:
|
Aperio AT2 |
| Authors: |
Delahoussaye AM, Abi Jaoude J, Green M, et al. |
| Study Goals: |
To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer. |
| Keywords: |
Aperio AT2 |
| |
|
|
|
|
Deep Learning of Histopathology Images at the Single Cell Level.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8461055 |
| Publication: |
Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641 |
| Institute: |
Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL |
|
Instrument:
|
Aperio AT2 |
| Authors: |
Lee K, Lockhart JH, Xie M, et al. |
| Study Goals: |
To systematically review the various machine learning methods with a focus on cell-level analysis. |
| Keywords: |
Aperio AT2 |
| |
|
|
|
|
Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging.
| Publication Year: |
2021 |
| Country: |
UK |
| PMID: |
PMC8073208 |
| Publication: |
Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 |
| Institute: |
Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB |
|
Instrument:
|
Aperio CS2 |
| Authors: |
Flint LE, Hamm G, Ready JD, et al. |
| Study Goals: |
To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. |
| Keywords: |
Aperio CS2 |
| |
|
|
|
|
Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats.
| Publication Year: |
2021 |
| Country: |
Taiwan |
| PMID: |
PMC8236591 |
| Publication: |
Frontiers in Neural Circuits. 2021;15. doi:10.3389/fncir.2021.693073 |
| Institute: |
Department of Life Science, National Taiwan University, Taipei |
|
Instrument:
|
Aperio CS2 |
| Authors: |
Kuo C-W, Chang M-Y, Liu H-H, et al. |
| Study Goals: |
To demonstrate a novel CES scheme with a theta-burst stimulation (TBS) protocol to identify the therapeutic potential of cortical electrical stimulation (CES) in a weight drop-induced rat model of traumatic brain injury (TBI). |
| Keywords: |
Aperio CS2 |
| |
|
|
|
|
Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors.
| Publication Year: |
2021 |
| Country: |
Taiwan |
| PMID: |
PMC7864566 |
| Publication: |
Science Advances. 2021;7(6). doi:10.1126/sciadv.abd0772 |
| Institute: |
Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Taoyuan |
|
Instrument:
|
Aperio CS2 |
| Authors: |
Chen K-T, Chai W-Y, Lin Y-J, et al. |
| Study Goals: |
To provide evidence of focused ultrasound (FUS)-induced immune modulation as an additional therapeutic benefit by converting the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME via a higher but safe FUS dosage. |
| Keywords: |
Aperio CS2 |
| |
|
|
|
|
Cardioprotective Effects of Palmitoleic Acid (C16:1n7) in a Mouse Model of Catecholamine-Induced Cardiac Damage Are Mediated by PPAR Activation.
| Publication Year: |
2021 |
| Country: |
Germany |
| PMID: |
PMC8657733 |
| Publication: |
International Journal of Molecular Sciences. 2021;22(23):12695. doi:10.3390/ijms222312695 |
| Institute: |
Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10115 Berlin |
|
Instrument:
|
Aperio CS2 |
| Authors: |
Betz IR, Qaiyumi SJ, Goeritzer M, et al. |
| Study Goals: |
C16:1n7 might have protective effects on cardiac fibrosis and inflammation. |
| Keywords: |
Aperio CS2 |
| |
|
|
|
|
Deep Learning of Histopathology Images at the Single Cell Level.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8461055 |
| Publication: |
Frontiers in Artificial Intelligence. 2021;4. doi:10.3389/frai.2021.754641 |
| Institute: |
Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL |
|
Instrument:
|
Aperio Versa |
| Authors: |
Lee K, Lockhart JH, Xie M, et al. |
| Study Goals: |
To systematically review the various machine learning methods with a focus on cell-level analysis. |
| Keywords: |
Aperio Versa, histopathology image analysis, deep learning, image data labeling, cell type classification, tumor immune microenvironment, tumor heterogeneity |
| |
|
|
|
|
NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice.
| Publication Year: |
2021 |
| Country: |
China |
| PMID: |
PMC8535822 |
| Publication: |
Science Advances. 2021;7(43). doi:10.1126/sciadv.abi9471 |
| Institute: |
State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital of Xiamen University, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, |
|
Instrument:
|
Aperio Versa |
| Authors: |
Zhang P, Liu Y, Hu L, et al. |
| Study Goals: |
To study NLRC4-mediated cell death and tissue damage |
| Keywords: |
Aperio Versa |
| |
|
|
|
|
In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8554823 |
| Publication: |
ACS Central Science. 2021;7(10):1638-1649. doi:10.1021/acscentsci.1c00529 |
| Institute: |
Department of Radiology and Biomedical Imaging |
|
Instrument:
|
Aperio Versa |
| Authors: |
Zhao N, Bardine C, Lourenço AL, et al. |
| Study Goals: |
To evaluate whether granzyme biochemistry can be assessed in vivo using an imaging modality that can be scaled vertically into human subjects |
| Keywords: |
Aperio Versa |
| |
|
|
|
|
Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8561005 |
| Publication: |
iScience. 2021;24(11):103245. doi:10.1016/j.isci.2021.103245 |
| Institute: |
Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco |
|
Instrument:
|
Aperio Versa |
| Authors: |
Das M, Mao W, Shao E, et al. |
| Study Goals: |
To understand whether Increased expression of TREM2 seems to support microglial activities that counteract AD related network dysfunction |
| Keywords: |
Aperio Versa |
| |
|
|
|
|
Computational Model-Based Estimation of Mouse Eyeball Structure From Two-Dimensional Flatmount Microscopy Images.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8088229 |
| Publication: |
Translational Vision Science & Technology. 2021;10(4):25. doi:10.1167/tvst.10.4.25 |
| Institute: |
Department of Mathematics and Statistics, Georgia State University, Atlanta, GA |
|
Instrument:
|
Imagescope/Aperio Software |
| Authors: |
Li H, Yu H, Kim Y-K, et al. |
| Study Goals: |
To investigate a a new method for estimating the three-dimensional (3D) eyeball sphere from two-dimensional tissue flatmount microscopy images |
| Keywords: |
Aperio CS2 |
| |
|
|
|
|
Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging.
| Publication Year: |
2021 |
| Country: |
UK |
| PMID: |
PMC8073208 |
| Publication: |
Metabolites. 2021;11(8):506. doi:10.3390/metabo11080506 |
| Institute: |
Centre for Mass Spectrometry Imaging, Biomolecular Research Centre, Sheffield Hallam University, Sheffield S1 1WB |
|
Instrument:
|
Imagescope/Aperio Software |
| Authors: |
Flint LE, Hamm G, Ready JD, et al. |
| Study Goals: |
To demonstrate that MALDI MSI as a promising tool for the investigation of histologically heterogeneous atherosclerotic plaques. |
| Keywords: |
Aperio CS2 |
| |
|
|
|
|
Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8698999 |
| Publication: |
Biomolecules. 2021;11(12):1766. doi:10.3390/biom11121766 |
| Institute: |
Department of Medicine, Georgetown University, Washington |
|
Instrument:
|
Imagescope/Aperio Software |
| Authors: |
Smith JP, Cao H, Edmondson EF, Dasa SSK, Stern ST. |
| Study Goals: |
To demonstrate the detection of early precancerous lesions (PanINs) in genetically engineered
mice. |
| Keywords: |
Aperio AT2, pancreatic cancer; cholecystokinin receptor; fluorescence; imaging; PanINs |
| |
|
|
|
Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model.
| Publication Year: |
2021 |
| Country: |
USA |
| PMID: |
PMC8848646 |
| Publication: |
BMC Cancer. 2022;22(1). doi:10.1186/s12885-022-09255-3 |
| Institute: |
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
|
Instrument:
|
BOND RX |
| Authors: |
Delahoussaye AM, Abi Jaoude J, Green M, et al. |
| Study Goals: |
To demonstrate the utility and feasibility of clinically relevant mFOLFIRINOX and gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer. |
| Keywords: |
BOND RX, Gemcitabine; KPC mice; Nab-paclitaxel; Pancreatic cancer; SBRT; mFOLFIRINOX |
| |
|
|
|
Stemness-Associated Markers Are Expressed in Extracranial Arteriovenous Malformation.
| Publication Year: |
2021 |
| Country: |
New Zealand |
| PMID: |
PMC8017302 |
| Publication: |
Frontiers in Surgery. 2021;8. doi:10.3389/fsurg.2021.621089 |
| Institute: |
Gillies McIndoe Research Institute, Wellington |
|
Instrument:
|
BOND RX |
| Authors: |
Luke Krishnan CS, Brasch HD, Patel J, et al. |
| Study Goals: |
Investigated the presence and expression pattern of OCT4, SOX2, NANOG, KLF4, and c-MYC in extracranial AVM |
| Keywords: |
BOND RX |
| |
|
|
