42 result(s) for 'Prostate'
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Prostate Biopsy Kits are a convenient means for the proper collection, identification and transportation of prostate biopsies. Kits
contain either 8, 12, or 16 prefilled 10% neutral buffered formalin containers arranged in prelabeled positions that correlate with the area of the prostate from which the sample was taken.
前列腺特异性膜抗原(PSMA)以750个氨基酸糖蛋白的形式表达,但也可能以PSM'的形式表达,PSM'是缺失前57个氨基酸的蛋白的一种形式。PSMA具有两种酶活性,一种是前列腺特异性整体膜叶酸水解酶,另一种是羧肽酶。报告显示PSMA表达可能与肿瘤负荷相关,并可作为转移受累的指标。PSMA的细胞定位与前列腺特异性抗原(PSA)和前列腺酸磷酸酶(PAP)的细胞定位形成鲜明对比。
前列腺特异性抗原(PSA)是一种34 kD的丝氨酸蛋白酶家族蛋白,最初是从人精浆中分离纯化而来。它被发现在免疫上是相同的,在生物学上类似于从前列腺中分离出来的一种蛋白质。PSA与前列腺酸磷酸酶不同。PSA在非前列腺组织和乳腺癌等肿瘤中的表达水平较低。
The transmembrane protease serine 2 gene (TMPRSS2) is involved in gene fusions with ERG, ETV1 or ETV4 in prostate cancer. It has been reported that the expression of the TMPRSS2-ERG fusion gene is a strong prognostic factor for the risk of prostate cancer recurrence in prostate cancer patients treated by surgery. The TMPRSS2-ERG rearrangement probe is optimized to detect the deletion between TMPRSS2 and ERG at 21q22 associated with the TMPRSS2-ER...
The androgen receptor (AR) gene has been identified as a target gene for the Xq12 amplification found in one-third of hormone-refractory prostate cancers. The findings suggest that AR gene amplification and overexpression is involved in the emergence of prostate cancer. The AR (Xq12) FISH probe is optimized to detect copy numbers of the AR gene region at region Xq12. The chromosome X satellite enumeration probe (SE X) at DXZ1 is included to facil...
Antigen Background
The expression of different cytokeratins in epithelial-derived tumors and the general tendency towards maintenance of cytokeratin polypeptide patterns during malignant growth and metastasis serves as a basis for approaching the characterization of tumors, using cytokeratins as differentiation markers.
Origin Cytokeratin (Clone 34?E12) is recommended for the characterization of squamous and ductal carcinomas arising from complex...
Antigen Background
p63 is a type II integral membrane protein predominantly localized in the rough endoplasmic reticulum. p63 is reported to be expressed in a number of normal tissues including proliferating cells of the epithelium, cervix, urothelium and prostate. p63 is also reported to be expressed in most poorly differentiated squamous cell carcinomas.
Disclaimer
p63 Protein is recommended for the detection of specific antigens of interest in...