Antigen Background Prostate specific antigen (PSA) is a 34 kD protein belonging to the kallikrein family of serine proteases and was originally isolated and purified from human seminal plasma. It was found to be immunologically identical and biologically similar to a protein isolated from the prostate gland. PSA is distinct from prostatic acid phosphatase. Low levels of expression of PSA have been reported in non-prostatic tissues and tumors such...

Prostate Biopsy Kits are a convenient means for the proper collection, identification and transportation of prostate biopsies. Kits contain either 8, 12, or 16 prefilled 10% neutral buffered formalin containers arranged in prelabeled positions that correlate with the area of the prostate from which the sample was taken.

Analyte Specific Reagent. Analytical and performance characteristics are not established. 

PROSTATE BIOPSY COREDISH 12 COMPARTMENT

Antigen Background Prostatic acid phosphatase (PAP) is an isoenzyme of acid phosphatase found in large amounts in the prostate and seminal fluid. The precise function of PAP is unknown, but it may act as a hydrolase to split phosphoryl choline in semen and also function as a transferase. Elevated serum levels of the enzyme are reported in metastatic prostatic carcinoma. Disclaimer Prostatic Acid Phosphatase is recommended for the detection of spe...

Antigen Background Androgen receptor is a member of the superfamily of ligand responsive transcription regulators. The androgen receptor functions in the nucleus where it is believed to act as a transcriptional regulator mediating the action of male sex hormones (androgens). The androgen receptor has wide distribution and can be demonstrated by immunohistochemistry in several tissues e.g. prostate, skin, and oral mucosa. Androgen receptor has bee...

Antigen Background E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In p...

Antigen Background The expression of different cytokeratins in epithelial-derived tumors and the general tendency towards maintenance of cytokeratin polypeptide patterns during malignant growth and metastasis serves as a basis for approaching the characterization of tumors, using cytokeratins as differentiation markers. Origin Cytokeratin (Clone 34?E12) is recommended for the characterization of squamous and ductal carcinomas arising from complex...