Articles
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H&E Image Quality & Tissue-based Research
H&E is an important tool for disease research and drug development and is being increasingly combined with digital pathology technology. Image quality is important for slide digitization to ensure that interpretation is accurate. Take a look at some images here, produced by our digital pathology scanners.
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Cryosectioning 101 for Research Q&A
In the webinar Cryosectioning 101 for Research, John Stock provided a comprehensive guide on achieving better cryosectioning outcomes. John went on to answer customer questions at the end of the session, that have been compiled for your viewing here.
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Tips & Tricks to Multiplexing: Top 5 Reasons to Multiplex and Chromogenic versus Immunofluorescent Detection
Multiplexing is an important tool for simultaneous detection of multiple markers within a single tissue section. These educational infographics highlight the 5 key reasons to multiplex, as well as the main considerations for choosing chromogenic or immunofluorescent detection.
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HISTOLOGY TIPS & TRICKS: QUESTIONS AND ANSWERS, Part 2
Following our 2-part webinar series of Tips & Tricks to Better Histology, questions about histology-related issues were received from customers and answered by Leica Biosystems. Here, in Histology Tips & Tricks: Questions and Answers, Part 2, more questions are answered, specifically regarding decalcifying agents, and tissue section bubbling/cracking.
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Multiplexing In Tissue-Based Research: Chromogenic Staining and Automation
Immunohistochemistry (IHC) detects proteins of interest within whole tissue sections, keeping cellular organization intact.
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Digital Pathology in Toxicological Pathology Studies
Drug development is a timely and costly process, with the average cost of bringing a single new drug to market costing $1.3 billion, taking anywhere between 10-15 years to finalize complete all clinical trials. Preclinical studies are the vital first steps in research and development and is estimated to cost $7M over 73 months. Up to 35% of drugs are eliminated at phase I and II clinical trials due to toxicity.
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Chromogenic Multiplex Biomarker Profiling of Human FFPE Tissues Using UltraPlex Technology
At the Multiplex User Meeting hosted via LabRoots, Helen Snyder, PhD delivered a live session detailing Cell IDx’s UltraPlex chromogenic multiplex IHC technology. Their chromogenic detection system of 3-4 markers simultaneously is developed to run on BOND RX autostainer in 4-5 hours, providing maximal information on small tissue samples for biomarker discovery.
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Enhanced Automated Multiplex Capabilities on Leica Biosystems BOND Research System
There is an ever-increasing demand to derive more information from limited research samples. Establishing expression profiles of the tumor microenvironment can be achieved via multiplex staining now with chromogenic detection. Discover how the new features of the Leica Biosystems BOND research system and new assays combine to support automated 6-plex chromogenic multiplexing.
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Tips & Tricks to Better Histology (Part 1): A Review of Key Factors Influencing the Quality of Tissue Preparation and Processing
In Part 1 of a two-part webinar series hosted originally on LabRoots, Fiona Tarbet gives a comprehensive overview focusing on how to mitigate the common issues experienced during histology that subsequently affect the stages of tissue preparation and processing.
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Tips & Tricks to Better Histology in Tissue-Based Research (Part 2): A Review of Factors Influencing the Quality of Sections
In Part 2 of a two-part webinar series hosted originally on LabRoots, Fiona Tarbet gives a comprehensive overview focusing on how to mitigate the common issues experienced during histology that subsequently affects the quality of sections and stains.