9 result(s) for 'Tonsil'
1 - 9 of 9 results for 'Tonsil'
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Antigen Background
CD1a is a protein of 43 to 49 kD expressed on dendritic cells and cortical thymocytes. CD1a antigen expression has been shown to be useful in differentiating Langerhans cells, powerful antigen presenting cells present in skin and epithelia, from interdigitating cells. Immunohistochemical studies for CD1a antigen have reported a reduction in epidermal Langerhans cells in graft versus host disease and the participation of CD1a an...
Antigen Background
The CD20 antigen is a non-glycosylated phosphoprotein of approximately 33kD which is expressed on normal and malignant human B cells and is thought to act as a receptor during B cell activation and differentiation. CD20 antigen has been reported to be expressed on normal B cells from peripheral blood, lymph node, spleen, tonsil, bone marrow, acute leukemias and chronic lymphocytic leukemias.
Disclaimer
CD20 is recommended for t...
Antigen Backgroundp16 (INK4a) (Cyclin-dependent kinase inhibitor 2A (CDKN2A)) is a tumour suppressor protein associated with cell cycle progression, specifically in the regulation of transition from G1 phase of the cell cycle in to the S phase. Oncogenic mutations in the CDKN2A gene that encodes p16 (resulting in over or under expression of the protein) is associated with a wide range of cancers and cancer precursor lesions.Disclaimerp16 is recom...
Antigen Background
Geminin is a protein of 209 amino acids thought to be involved in the control of DNA replication via the interaction with Cdt1. Geminin is not found in the G1 phase of the cell cycle, but is first expressed in the G1 to S transition phase, with expression levels rising through the rest of the cell cycle and levels reaching a maximum during mitosis. It has been proposed that geminin may be a tumor suppressor protein. Geminin is ...
Antigen Background Mesothelin is a glycosyl-phosphatidylinositol-linked (GPI) glycoprotein of 40kD present on the surface of mesothelial cells, mesotheliomas, epithelial ovarian cancers and some squamous cell carcinomas. It is synthesized as a 69 kD precursor which is enzymatically processed into an N-terminal secreted form of 30 kD and the GPI-linked membrane-bound form of 40 kD. The secreted form is identical to the megakaryocyte potentiating f...
Antigen Background LAG-3 (Lymphocyte Activation gene 3, CD223) is a 503 amino acid transmembrane protein. It plays a role in the negative regulation of cellular proliferation & activation of T-cells in a similar manner to CTLA-4 and PD-1. LAG3 plays a role in the exhaustion of T-cell responses in cancer, and is therefore the subject of extensive research in conjunction with other related immunomodulatory markers. Disclaimer LAG-3 is recommended f...
Antigen Background FOXP3 (Forkhead Box Protein 3, Scurfin) is a member of the forkhead box (FOX) famly of transcription factors. These proteins are characterised by a highly-conserved forkhead DNA-binding domain. FOXP3 has an important role in immune regulation, with its effect in reducing Interleukin-2 expression causing a reduced function of T-helper cells. The role of FOXP3 in cancer is multifaceted, with roles in both tumour progression (via ...
Antigen BackgroundTIM-3 (T-cell Immunoglobulin and Mucin Domain-Containing 3, Hepatitis A Virus Cellular Receptor, HAVCR2). TIM-3 is a Type I transmembrane that can be expressed on both tumour and immune cells. It is expressed on multiple immune cells, including type 1 T helper (Th1) cells, Th17 and CD8+ T cells, Tumour Infiltrating Lymphocytes, regulatory T cells (Tregs) and innate immune cells.DisclaimerTIM-3 is recommended for the detection of...
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