3 result(s) for 'Tonsil'
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Antigen Background LAG-3 (Lymphocyte Activation gene 3, CD223) is a 503 amino acid transmembrane protein. It plays a role in the negative regulation of cellular proliferation & activation of T-cells in a similar manner to CTLA-4 and PD-1. LAG3 plays a role in the exhaustion of T-cell responses in cancer, and is therefore the subject of extensive research in conjunction with other related immunomodulatory markers. Disclaimer LAG-3 is recommended f...
Antigen Background FOXP3 (Forkhead Box Protein 3, Scurfin) is a member of the forkhead box (FOX) famly of transcription factors. These proteins are characterised by a highly-conserved forkhead DNA-binding domain. FOXP3 has an important role in immune regulation, with its effect in reducing Interleukin-2 expression causing a reduced function of T-helper cells. The role of FOXP3 in cancer is multifaceted, with roles in both tumour progression (via ...
Antigen BackgroundTIM-3 (T-cell Immunoglobulin and Mucin Domain-Containing 3, Hepatitis A Virus Cellular Receptor, HAVCR2). TIM-3 is a Type I transmembrane that can be expressed on both tumour and immune cells. It is expressed on multiple immune cells, including type 1 T helper (Th1) cells, Th17 and CD8+ T cells, Tumour Infiltrating Lymphocytes, regulatory T cells (Tregs) and innate immune cells.DisclaimerTIM-3 is recommended for the detection of...