62 result(s) for 'Lung'
21 - 30 of 62 results for 'Lung'
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Antigen Background
Alpha-methylacyl-CoA racemase (AMACR), also known as p504s, is a mitochondrial and peroxisomal enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism, and is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon...
Deletions of chromosome 13q14 have been reported not only in CLL but in a variety of human tumors, including other types of lymphoid and myeloid tumors, as well as prostate, head and neck, and non-small cell lung cancers. The deletion of 13q may be limited to a single locus (13q14), or accompanied with the loss of a larger interstitial region of the long arm of chromosome 13. A minimal critical region of 400 kb has been described containing the D...
The ERBB2 (or HER2) gene encodes a receptor tyrosine kinase involved in growth factor signaling. Overexpression of this gene is seen in about 20% of invasive breast cancers. ERBB2 gene amplification is a permanent genetic change that results in this continuous overexpression of ERBB2. ERBB2 amplification is also observed in a variety of other tumors, such as gastric, prostate, lung, colon and ovary carcinoma. The ERBB2 (17q12) FISH probe is optim...
Antigen Background
The myotilin gene on chromosome 5q31 encodes a 498 amino acid polypeptide with a molecular weight of 57kD. Myotilin is a structural protein of sarcomeric Z discs and sarcolemma in human skeletal and cardiac muscle. It is homologous to palladin and titin in the two C-terminal lg-domains and also to palladin in its unique serine-rich N-terminal region. Myotilin interacts with alpha-actinin, actin and gamma-filamin. Mutations in t...
The MET proto-oncogene is a receptor-like tyrosine kinase that drives a physiological cellular program important for development, cell movement, cell repair and cellular growth. Aberrant execution of this program has been associated to neoplastic transformation, invasion and metastasis. Activation of MET has been reported in a significant percentage of human cancers including non-small cell lung cancer (NSCLC) and is amplified during the transiti...
Epidermal growth factor receptor (EGFR) is a cell membrane protein, providing signal transduction and cell growth. It is a member of the Erb-B family of type I receptor tyrosine kinases and implicated in the development and progression of non-small cell lung carcinomas (NSCLC), breast, intestine, and other organs. EGFR has been found to act as a strong prognostic indicator in head and neck, ovarian, cervical, bladder and oesophageal cancers. In t...
Translocations of the ALK (anaplastic lymphoma kinase) gene at 2p23 have originally been associated with anaplastic lymphomas, B-cell lymphomas, neuroblastomas and myofibroblastic tumors. At least 21 translocation partners have been described, however 80% of the translocations involves the NPM1 gene (5q35). ALK rearrangements have been described in non-small cell lung cancer (NSCLC) cases. Multiple tyrosine kinsae inhibitors (TKI's) specific for ...
The MET proto-oncogene is a receptor-like tyrosine kinase that drives a physiological cellular program important for development, cell movement, cell repair and cellular growth. Aberrant execution of this program has been associated to neoplastic transformation, invasion and metastasis. Activation of MET has been reported in a significant percentage of human cancers including non-small cell lung cancer (NSCLC) and is amplified during the transiti...
Epidermal growth factor receptor (EGFR) is a cell membrane protein, providing signal transduction and cell growth. It is a member of the Erb-B family of type I receptor tyrosine kinases and implicated in the development and progression of non-small cell lung carcinomas (NSCLC), breast, intestine, and other organs. EGFR has been found to act as a strong prognostic indicator in head and neck, ovarian, cervical, bladder and oesophageal cancers. In t...
Antigen Background Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-...