4 result(s) for 'CD4'
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Antigen Background
The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes and at a lower level on monocytes and germinal center macrophages. Most cases of cutaneous T cell lymphoma, including mycosis fungoides, express the CD4 antigen and HTLV-1 associated adult T cell leukemia/lymphoma is...
Antigen Background
The CD45RO molecule, a 180 kD isoform of CD45, is reported to be expressed on 48% of peripheral blood T lymphocytes, 37% of CD4 positive lymphocytes, 80% of thymocytes and on the majority of T cell malignancies. Monocytes and granulocytes show surface expression of the antigen whereas tissue macrophages exhibit cytoplasmic expression.
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CD45RO is recommended for the detection of specific antigens of interest in normal ...
Antigen Background
The CD45 antigen (leukocyte common antigen) is a family of five or more high molecular weight glycoproteins present on the surface of the majority of the human leukocytes (including lymphocytes, monocytes and eosinophils) but absent from erythrocytes and platelets. Various isoforms of CD45 are generated by alternative splicing of three exons. Expression of CD45 is necessary for signaling through the T cell receptor.
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Antigen Background
The CD43 antigen is expressed on the membrane and in the cytoplasm of T cells and cells of myeloid lineage. The molecule itself exhibits molecular weight heterogeneity with bands of 90 to 140 kD observed on SDS-PAGE between different cell lines. Cells expressing the CD43 antigen are reported to include normal and neoplastic T cells. A small proportion of B cell chronic leukemias and diffuse large B cell lymphomas are also repor...