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Antigen Background
Keratins are a family of water insoluble proteins of 40 to 70 kD. These proteins form tonofilaments, a class of intermediate filament, in epidermis as well as in almost all other epithelia. The process of normal epidermal differentiation is characterized by a series of morphological and biochemical changes as cells progress from the germinative basal layer through the spinous and granular layers to the outer cornified layer. Th...