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Aperio Membrane Algorithm – Rapid Cell Membrane Analysis

Aperio Membrane Algorithm

The Aperio Membrane Algorithm detects membrane staining for individual tumor cells in a selected region, and quantifies the intensity and completeness of the membrane staining. Use the Aperio Membrane Algorithm to measure expression of IHC biomarkers specifically within the cell membrane, while excluding staining in other subcellular compartments (cytoplasm, nucleus). 

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Highly specific analysis

Tunable algorithm settings let you precisely define parameters for cells to be analyzed, including size, shape and membrane staining intensity and completeness. Analyze only the cells that are of interest for your research.

Analyze the right tissue

Analysis can be run on fields of view, annotated regions, or whole slides. Pre-process slides with Aperio GENIE for auto-selection of tumor, removing the need for manual annotation.

Scoring that fits your preferences

You set the parameters that define scoring classes (0, 1+, 2+, 3+) so your algorithm can be adjusted for variations in staining due to reagent choice or slide preparation.

Easy to review results

Analyzed regions are overlaid with a color coded mark-up in Aperio ImageScope for simple visual review of the data. Aperio Membrane Algorithm assigns an overall score, but also shows the absolute percentage of cells in each scoring class, so you can make a determination in borderline cases.

Key download

 Brochure (pdf)

 Case Study (pdf)

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Aperio RUO (Research Use Only) Image Analysis Algorithms have been validated by Leica Biosystems for use with .svs images from Aperio AT2, Aperio CS2, and Aperio VERSA scanners. Use of Aperio RUO Algorithms with other available scanners has not been validated, and Leica Biosystems cannot train or support customers in use of Aperio RUO Algorithms with images from these scanners.