2 result(s) for 'Histopathology'
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Antigen Background The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells.Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indi...
Antigen Background
Human herpesvirus type 8 (HHV8), is the proposed etiological agent of Kaposi's sarcoma (KS). It is reported that HHV8 has been demonstrated in KS tissues by immunohistochemistry, in situ PCR and also in situ hybridization. HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene ORF73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product which may be related to its oncoge...