6 result(s) for 'Histopathology'
1 - 6 of 6 results for 'Histopathology'
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Antigen Background
Mammaglobin is a 10 kDa glycoprotein that belongs to the uteroglobin family of proteins. It was first described in 1996 and found to be overexpressed in breast cancer. Mammaglobin has been suggested as a useful marker for carcinomas of unknown primary origin, with expression unaltered from the primary site.
Disclaimer
Mammaglobin is recommended for the detection of specific antigens of interest in normal and neoplastic tissues...
Antigen Background
This monoclonal antibody recognizes both wild type and mutant forms of human p53 protein under denaturing and non-denaturing conditions. The epitope recognized by clone DO-7 can be destroyed by prolonged fixation in buffered formalin. The heat induced epitope retrieval technique may improve staining in some cases.
Disclaimer
p53 Protein is recommended for the detection of specific antigens of interest in normal and neoplastic t...
Antigen Background
p120 Catenin is a regulator of cell-cell adhesion, achieved through interaction with classical and Type II cadherins. Evidence also exists for a role in the regulation of cadherin availability on the cell surface. p120 Catenin also regulates actin dynamics, placing it as a potential master regulator of the cell motility/cell adhesion phenotypes.Recent studies have suggested a tumor-suppression role for p120, with loss of p120 e...
Antigen BackgroundThe human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. In vitro studies have indicated that PRA and PRB can activate different target genes and that PRA, in some circumstances, may act as a dominant inhibitor of the function of PRB and other steroid hormone receptors. PRA and PRB are both expressed in normal breast. Most endometri...
Antigen Background The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene. The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the...
Antigen Background
The c-erbB-2 oncoprotein is closely related in structure to the epidermal growth factor receptor and is a member of a large family of cell surface growth factor receptors. c-erbB-2 oncoprotein is reported to be detectable in a proportion of breast and other adenocarcinomas as well as transitional cell carcinomas. c-erbB-2 oncoprotein is present in a wide variety of cell types in a range of normal human fetal and adult tissues,...