2 result(s) for 'Histopathology'
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Antigen BackgroundThe human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. In vitro studies have indicated that PRA and PRB can activate different target genes and that PRA, in some circumstances, may act as a dominant inhibitor of the function of PRB and other steroid hormone receptors. PRA and PRB are both expressed in normal breast. Most endometri...
Antigen Background Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-...