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Varying the approach angle in stereotaxic surgery can overcome the conflict between positional accuracy and interpretability. Fortunatly modern computer controlled stereotaxic instrumets make this possible.
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To prepare biological tissue for observation under a microscope, the tissue is usually cut in thin slices. Most biological tissue is too soft to cut; the knife would push into it and compress it, even if the cutting edge was very sharp. Therefore, the tissue is either frozen and sectioned…
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Together with a suitable manipulator and oriented head holder, brain maps can be used to position probes at a preplanned site in the brains of several rodents. The instrument for moving a probe to a given coordinate in space – inside the brain – is a stereotaxic instrument.
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Brain damage from football, improvised explosive devices, and childhood falls has spurred a surge of funding for research on impact brain damage. Damage seems to result in slow growth of tangles of Tau proteins at the damaged sites, but behavioral changes due to the damage may not appear…